Assessment & Research

Risk factors for autism and Asperger syndrome. Perinatal factors and migration.

Haglund et al. (2011) · Autism : the international journal of research and practice 2011
★ The Verdict

Birth complications and maternal birth in sub-Saharan Africa or East Asia raise autism risk, but not Asperger risk.

✓ Read this if BCBAs who assess or treat young children with autism and want full case context.
✗ Skip if Clinicians only working with older Aspie clients or genetic-only teams.

01Research in Context

01

What this study did

The team looked at every child born in Sweden across several years.

They checked birth records for problems like low oxygen or early delivery.

They also noted where each mother was born.

Then they counted which children later got an autism or Asperger diagnosis.

02

What they found

Babies who had birth complications were more likely to receive an autism label.

The risk was highest when moms came from sub-Saharan Africa or East Asia.

Surprisingly, these factors did not raise the odds of Asperger syndrome.

Migration plus obstetric stress mattered for autism, but not for the milder form.

03

How this fits with other research

Bröring et al. (2018) extends the story: they show that very pre-term children display clear ASD symptoms at school age.

Their data add a timeline, proving that early birth complications can still shine through years later.

Hoksbergen et al. (2005) also extends the idea, but with a twist: severe early neglect in Romanian adoptees produced autism-like behaviors that eased with longer, stable care.

Both papers point to early adversity—biological or social—as a pivot point for later traits.

Burrows et al. (2018) offers a caution: maternal mood and education can tilt caregiver ratings.

So some of the risk we see may be boosted by how moms report, not just biology.

04

Why it matters

When you see a new client with autism, ask about birth history and family origin.

If mom mentions a tough delivery or that she grew up in Africa or Asia, note it, but do not treat it as destiny.

Use the info to watch for co-occurring medical issues, not to lower expectations.

Pair this history with solid assessment tools and keep your intervention goals high and clear.

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02At a glance

Intervention
not applicable
Design
other
Sample size
250
Population
autism spectrum disorder
Finding
positive

03Original abstract

Using the Swedish Medical Birth Registry (MBR), obstetrical and demographic information was retrieved for 250 children with autism or Asperger syndrome who were born in Malmoe, Sweden, and enrolled at the local Child and Youth Habilitation Center. The reference group consisted of all children born in Malmoe during 1980-2005. Obstetric sub-optimality (prematurity, low Apgar scores, growth restriction, or macrosomia) was positively associated with autism but not with Asperger syndrome. Maternal birth outside the Nordic countries was positively associated with autism (adjusted OR: 2.2; 95%CI: 1.6-3.1) and negatively associated with Asperger syndrome (OR: 0.6; 95%CI: 0.3-0.97). The highest risk estimate for autism was found among children to women who were born in sub-Saharan Africa (OR: 7.3), or in East Asia (OR: 3.4).

Autism : the international journal of research and practice, 2011 · doi:10.1177/1362361309353614