Assessment & Research

A case-control study of obstetric complications and later autistic disorder.

Cryan et al. (1996) · Journal of autism and developmental disorders 1996
★ The Verdict

Birth complications do not separate children who later get an autism diagnosis from those who do not.

✓ Read this if BCBAs who include birth-history questions in intake or parent interviews.
✗ Skip if Clinicians already focused on skill-based assessment and current environmental variables.

01Research in Context

01

What this study did

Cryan et al. (1996) pulled obstetric records for children later diagnosed with autism.

They compared each record with a matched control child of the same sex, birth weight, and delivery hospital.

The team scored every pregnancy and birth event to see if autism cases had more complications.

02

What they found

The autism and control groups earned almost identical complication scores.

No single obstetric event stood out as more common in the children who later received an autism diagnosis.

03

How this fits with other research

Dall et al. (1997) repeated the design the next year and got the same null result, this time using siblings as controls.

Gillberg et al. (1983) had earlier reported more prenatal problems in autistic children, but that study looked at a whole city population without tight matching; the different control method likely explains the clash.

Howard et al. (1988) looked IQ-matched groups and actually saw fewer problems in the autistic sample except for one birth-position difference; again, matching choices shape the story.

More recent work extends the question: Lancioni et al. (2008) and Chien et al. (2019) find that while complications do not cause autism, high blood pressure or diabetes during pregnancy can slightly raise the child’s later symptom severity scores.

04

Why it matters

You can stop asking parents to hunt for birth trauma clues during intake. Obstetric records will not tell you which toddlers will land on the spectrum, and they will not predict how hard the road will be for the child in front of you. Save interview time for current skill gaps and reinforcement history instead of birth stories.

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Drop routine obstetric history questions from your intake form and replace them with a quick scan of current reinforcement available for communication and toleration responses.

02At a glance

Intervention
not applicable
Design
case study
Sample size
49
Population
autism spectrum disorder
Finding
null

03Original abstract

The precise etiology of autism remains unclear. Obstetric adversity has been described as one factor that may increase the risk for the disorder. We examined the contemporaneous birth records of 49 children satisfying DSM-III-R criteria for autistic disorder, at four Dublin maternity hospitals, using the previous same-sex live birth in that hospital as a control. Data were evaluated blind to subject status using two obstetric complication (OC) rating scales. No significant differences in obstetric adversity were found between index and control groups. Autistic individuals did not differ from controls in terms of previously described risk factors for this disorder (maternal age, maternal parity, birth order, and low birth weight) in autism. These data do not support the view that OCs increase the risk for later autism.

Journal of autism and developmental disorders, 1996 · doi:10.1007/BF02172829