Autism & Developmental

Obstetric and parental psychiatric variables as potential predictors of autism severity.

Wallace et al. (2008) · Journal of autism and developmental disorders 2008
★ The Verdict

High blood pressure during pregnancy and parental depression each nudge autism severity scores slightly higher, so track both medical and family mental health history.

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01Research in Context

01

What this study did

Researchers looked at the kids with autism. They checked medical records for pregnancy problems. They also asked parents about their own mental health.

Then they linked these facts to two autism tests: the ADI-R and the ADOS.

02

What they found

Kids whose moms had high blood pressure during pregnancy scored slightly worse on the ADI-R. The difference was small but real.

Surprisingly, kids with anxious parents scored slightly better on the ADOS. Again, the effect was tiny.

03

How this fits with other research

Taylor et al. (2017) extends this work. They found that moms who faced two or more big stress events while pregnant had kids with worse autism symptoms. This supports the idea that prenatal stress matters.

Yorke et al. (2018) pulls together 40 studies. Their meta-analysis shows that when kids have extra behavior problems, parents feel more stress and depression. This creates a feedback loop.

O'Dwyer et al. (2018) adds another piece. They found that higher ADOS scores in kids directly raise mom's stress. This helps explain why parental anxiety might show up in the data.

Fairthorne et al. (2016) looked at the bigger picture. They found that any mom with past mental health treatment had double the chance of having a child with autism. This sets the stage for the parental depression finding.

04

Why it matters

You can't change pregnancy history, but you can screen for parent mental health. When you see a child with high ADI-R scores, ask about mom's pregnancy. When you see anxious parents, don't assume their child is less affected. Instead, offer parent support services. Small effects add up when families face both biological and psychological stress.

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Add one question to your intake form: 'Did mom have high blood pressure or preeclampsia during pregnancy?'

02At a glance

Intervention
not applicable
Design
other
Sample size
228
Population
autism spectrum disorder
Finding
mixed
Magnitude
small

03Original abstract

Associations between obstetric and parental psychiatric variables and subjects' Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) domain scores were examined using linear mixed effects models. Data for the 228 families studied were provided by the Autism Genetic Resource Exchange. Hypertension (P = 0.002), preeclampsia (P = 0.021) and generalized edema (P = 0.011) were associated with higher ADI-R communication scores. Hypertension (P = 0.011), albuminuria (P = 0.039) and generalized edema (P = 0.009) were associated with higher ADI-R repetitive behaviors scores. Parent depression was associated with higher ADI-R repetitive behaviors scores (P = 0.005), and parent anxiety with lower ADOS social/communication composite scores (P = 0.025). The associations between hypertension-related obstetric conditions and autistic severity warrant further investigation and raise intriguing questions regarding potential causal and modifying factors in autism.

Journal of autism and developmental disorders, 2008 · doi:10.1007/s10803-007-0536-4