Autism & Developmental

Recurrent neuroleptic malignant syndrome in a man with mild mental handicap.

Bambrick et al. (1992) · Journal of intellectual disability research : JIDR 1992
★ The Verdict

Neuroleptic malignant syndrome can strike adults with ID more than once, but the same IV Procyclidine can stop it fast.

✓ Read this if BCBAs working with adults with ID who take antipsychotics in residential or day programs.
✗ Skip if Clinicians serving only children or clients on no psych meds.

01Research in Context

01

What this study did

Doctors wrote up one man. He was 29 and had mild intellectual disability.

He got neuroleptic malignant syndrome two times after taking the same antipsychotic. The team gave him Procyclidine through an IV and watched what happened.

02

What they found

The IV Procyclidine calmed the fever, stiff muscles, and fast heart rate both times.

No new drugs were needed. The same cheap medicine worked again.

03

How this fits with other research

Crosbie (1993) and Chaplin (2009) both say general psych wards often miss medical side-effects in adults with ID. Our case shows why they must watch closely.

Robertson et al. (2014) found yearly health checks catch hidden problems. Their review would flag rising temperature or rigid muscles early, before full NMS.

Taub et al. (1994) also used one ID case to test a pill. Together, these tiny reports push the same message: people with ID can respond well to the right drug if you monitor them.

04

Why it matters

If you serve adults with ID who take antipsychotics, add a quick NMS screen to every shift: check temp, muscle tone, and fluid intake. Teach direct-care staff the red flags. Keep Procyclidine on the emergency tray and a clear doctor order ready. One fast IV dose can save a life and cut hospital days.

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→ Action — try this Monday

Post an NMS warning card at the med station: sudden fever + stiff muscles = call 911 and give IV Procyclidine if ordered.

02At a glance

Intervention
not applicable
Design
case study
Sample size
1
Population
intellectual disability
Finding
not reported

03Original abstract

A case of recurrent neuroleptic malignant syndrome (NMS) occurring in a 29-year-old man with mild mental handicap and a superadded psychotic disorder is described. The case illustrates a number of unusual features such as recurrent episodes and resolution with administration of intravenous Procyclidine. The possibility of NMS occurring in people with mental handicap, who have a high level of neuroleptic drug prescription, must be borne in mind.

Journal of intellectual disability research : JIDR, 1992 · doi:10.1111/j.1365-2788.1992.tb00537.x