Autism & Developmental

Brief report: identical male twins concordant for Asperger's disorder.

Ishijima et al. (2007) · Journal of autism and developmental disorders 2007
★ The Verdict

Identical twins with Asperger’s can show very different IQ, motor, and mood profiles, so treat each child as unique.

✓ Read this if BCBAs completing intake assessments on twin clients or siblings with ASD.
✗ Skip if Clinicians who only serve single-child families.

01Research in Context

01

What this study did

Ishijima et al. (2007) watched two identical twin boys who both had Asperger’s.

The team wrote down every difference they saw in IQ, motor skills, and extra diagnoses.

They wanted to know if same DNA always means same autism picture.

02

What they found

Even with matching genes, the twins did not match in skills or needs.

One boy scored higher on IQ tests; the other had weaker motor control.

The paper shows genes alone can’t predict how Asperger’s will look.

03

How this fits with other research

Lawer et al. (2009) scanned brains of twin pairs who were split: one twin autistic, one not.

They found extra brain folds in both twins, hinting that non-genetic factors still shape the brain.

The scan study extends Michiko’s idea: identical genes can still lead to different brains and behaviors.

Helles et al. (2017) followed Asperger men for twenty years and saw wide life-outcome gaps.

Their long view agrees with the twin case: shared DNA does not lock in shared future.

04

Why it matters

When you meet identical twins on your caseload, treat them as two separate kids.

Use individual assessments for IQ, motor, and mood even when DNA is the same.

Plan different goals, because genetics only sets the stage; environment and learning write the script.

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Run separate VB-MAPP or AFLS assessments for each twin before writing goals.

02At a glance

Intervention
not applicable
Design
case study
Sample size
2
Population
autism spectrum disorder
Finding
not reported

03Original abstract

The first case study of identical male twins concordant for DSM-IV Asperger's disorder (ASD) was presented. Their monozygocity was confirmed by short tandem repeat analyses with a probability of 99.999963%. Despite sharing the same DNA and environment, the twins are different in comorbidity (i.e., major depressive disorder in the elder and absence seizure in the younger) and in IQs and motor performance (i.e., the elder was lower in IQs and clumsier). Both of them were normal in computed tomographic scanning and magnetic resonance imaging discordant with some previous reports of brain imaging abnormalities in ASD. Further studies are needed to clarify inherited/acquired epigenetic defects and brain imaging abnormalities relating to behavioral phenotypes in ASD twins.

Journal of autism and developmental disorders, 2007 · doi:10.1007/s10803-006-0150-x