Asperger syndrome: familial and pre- and perinatal factors.
Half of boys with Asperger Syndrome have autism traits on dad’s side, and a quarter faced prenatal or birth complications.
01Research in Context
What this study did
Gillberg et al. (2005) looked back at medical charts of boys with Asperger Syndrome. They asked two questions: Does autism run in the father’s family? Did anything go wrong during pregnancy or birth?
What they found
Fifty-five percent of the boys had a father or paternal relatives with autism traits. One in four also had prenatal or birth complications. Family history and early risk factors both showed up in the same kids.
How this fits with other research
Guisso et al. (2018) later found the same kinds of risks in Lebanese children, plus new ones like mom’s infections. The picture keeps growing.
Puleo et al. (2012) narrowed the lens to dad’s age. They saw more autism in girls with older fathers, but not in boys. Christopher’s paternal link is broader; Morrow’s is age-specific.
Day-Watkins et al. (2014) added detail: fathers of autistic kids often show mild “broad autism” traits themselves. This backs the family-story data Christopher saw.
Why it matters
When you meet a new client, ask about dad’s side of the family and any pregnancy or birth events. If either pops up, plan extra screening for siblings and watch for medical issues that can affect learning. The intake form you already use just got two new must-check boxes.
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02At a glance
03Original abstract
OBJECTIVE: Study familial and pre- and perinatal factors in Asperger Syndrome (AS). METHODS: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage. RESULTS: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%. COMMENT: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.
Journal of autism and developmental disorders, 2005 · doi:10.1007/s10803-004-1993-7