Autism & Developmental

Asperger syndrome: familial and pre- and perinatal factors.

Gillberg et al. (2005) · Journal of autism and developmental disorders 2005
★ The Verdict

Half of boys with Asperger Syndrome have autism traits on dad’s side, and a quarter faced prenatal or birth complications.

✓ Read this if BCBAs writing intake histories or explaining risk to parents.
✗ Skip if Clinicians who only run skill-acquisition sessions and never touch assessment.

01Research in Context

01

What this study did

Gillberg et al. (2005) looked back at medical charts of boys with Asperger Syndrome. They asked two questions: Does autism run in the father’s family? Did anything go wrong during pregnancy or birth?

02

What they found

Fifty-five percent of the boys had a father or paternal relatives with autism traits. One in four also had prenatal or birth complications. Family history and early risk factors both showed up in the same kids.

03

How this fits with other research

Guisso et al. (2018) later found the same kinds of risks in Lebanese children, plus new ones like mom’s infections. The picture keeps growing.

Puleo et al. (2012) narrowed the lens to dad’s age. They saw more autism in girls with older fathers, but not in boys. Christopher’s paternal link is broader; Morrow’s is age-specific.

Day-Watkins et al. (2014) added detail: fathers of autistic kids often show mild “broad autism” traits themselves. This backs the family-story data Christopher saw.

04

Why it matters

When you meet a new client, ask about dad’s side of the family and any pregnancy or birth events. If either pops up, plan extra screening for siblings and watch for medical issues that can affect learning. The intake form you already use just got two new must-check boxes.

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Add two quick questions to your intake: “Any autism traits in dad’s family?” and “Any pregnancy or birth problems?”

02At a glance

Intervention
not applicable
Design
case series
Sample size
100
Population
autism spectrum disorder
Finding
not reported

03Original abstract

OBJECTIVE: Study familial and pre- and perinatal factors in Asperger Syndrome (AS). METHODS: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage. RESULTS: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%. COMMENT: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.

Journal of autism and developmental disorders, 2005 · doi:10.1007/s10803-004-1993-7