Autism & Developmental

Additive or Interactive Associations of Food Allergies with Glutathione S-Transferase Genes in Relation to ASD and ASD Severity in Jamaican Children.

Saroukhani et al. (2024) · Journal of autism and developmental disorders 2024
★ The Verdict

Dairy allergy plus certain gene variants nudges repetitive behavior scores a bit higher in Jamaican kids with autism.

✓ Read this if BCBAs working with children who have both autism and documented food allergies.
✗ Skip if BCBAs focused solely on skill acquisition or behavior reduction without medical comorbidities.

01Research in Context

01

What this study did

Researchers looked at 169 Jamaican children. Half had autism. Half did not.

They checked each child for food allergies. They also tested their genes for GST variants.

Then they compared ADOS-2 scores to see if allergy plus gene combo changed repetitive behaviors.

02

What they found

Kids with autism who had both dairy allergy and certain GST genes scored a little higher on repetitive behaviors.

The effect was small. It did not change who got an autism diagnosis.

Other food allergies like egg or peanut showed no clear link.

03

How this fits with other research

Marí-Bauset et al. (2016) showed kids on a gluten-free casein-free diet often lack vitamin D and calcium. Their study focused on nutrition after removing dairy. Saroukhani et al. (2024) instead links dairy allergy plus genes to behavior. The two papers talk about dairy but answer different questions.

Raz et al. (2015) tracked a 10-fold rise in autism cases in Israel. Pinborough-Zimmerman et al. (2012) saw a similar doubling in Utah records. These studies describe how many kids get identified. Saroukhani et al. (2024) looks inside already-identified kids to find tiny biological differences.

Carnett et al. (2020) taught preschoolers to ask "where" questions with a speech device. Their work shows what we can change. Saroukhani et al. (2024) shows what we cannot change. Both help us understand autism better.

04

Why it matters

You do not need to screen every child for GST genes. The effect is too small to guide daily practice. Instead, keep watching for food reactions that worsen repetitive behaviors. If a child with autism also has dairy allergy, note any spike in stereotypy after milk. Simple ABC data still beats gene tests.

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Track one week of ABC data on repetitive behavior before and after dairy exposure for any client with known milk allergy.

02At a glance

Intervention
not applicable
Design
other
Sample size
344
Population
autism spectrum disorder, neurotypical
Finding
weakly positive
Magnitude
small

03Original abstract

To investigate additive and interactive associations of food allergies with three glutathione S-transferase (GST) genes in relation to ASD and ASD severity in Jamaican children. Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of food allergies with polymorphisms in GST genes (GSTM1, GSTP1 and GSTT1) in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domains specific comparison scores (CSs) by fitting general linear models. Although food allergies and GST genes were not associated with ASD, ASD cases allergic to non-dairy food had higher mean ADOS-2 Restricted and Repetitive Behaviors (RRB) CS (8.8 vs. 8.0, P = 0.04). In addition, allergy to dairy was associated with higher mean RRB CS only among ASD cases with GSTT1 DD genotype (9.9 vs. 7.8, P < 0.01, interaction P = 0.01), and GSTP1 Val/Val genotype under a recessive genetic model (9.8 vs. 7.8, P = 0.02, interaction P = 0.06). Our findings are consistent with the role for GST genes in ASD and food allergies, though require replication in other populations.

Journal of autism and developmental disorders, 2024 · doi:10.1093/aje/kwu112