Measurement of Sleep Behaviors in Chromosome 15q11.2-13.1 Duplication (Dup15q Syndrome).

The team asked the caregivers of kids with dup15q syndrome to fill out the Children’s Sleep Habits Questionnaire.

They also noted if the child had epilepsy.

This was a simple survey study—no fancy gadgets, just paper forms.

Caregivers said most kids had big sleep problems.

But here’s the twist: kids with epilepsy scored even worse on the same form.

So epilepsy, not just dup15q, drives the high sleep-disturbance numbers.

Udhnani et al. (2025) looked at autistic adults and found sleep trouble vanished once anxiety and depression were counted out.

That seems to clash with Barstein et al. (2021), but the difference is epilepsy.

In dup15q, seizures—not autism—push the scores up, while in the adult study mood ruled the night.

Wong et al. (2023) saw the same pattern in FOXG1 syndrome: over half the kids had sleep issues, backing up that rare genetic disorders often come with poor sleep.

Paavonen et al. (2008) also showed more than half of kids with Asperger syndrome had sleep problems, so the story keeps repeating across diagnoses.

Before you trust a high CSHQ score in a child with dup15q, ask about seizures.

If epilepsy is active, treat that first; the sleep data may then look very different.