Autism & Developmental

Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study.

Richler et al. (2006) · Journal of autism and developmental disorders 2006
★ The Verdict

No evidence links the MMR vaccine to regressive autism; kids with regression just show slightly lower verbal skills and more GI issues.

✓ Read this if BCBAs who coach families worried about vaccines or who assess kids with language loss.
✗ Skip if Clinicians only working with adults or with clients who have no regression history.

01Research in Context

01

What this study did

Richler et al. (2006) asked a simple question. Do kids who lose skills after the MMR shot have a special kind of autism?

They looked at children with autism who had lost words or other skills. They checked if those kids got the MMR shot right before the loss.

They also compared the kids who lost skills with kids who did not. They wanted to see if the two groups looked different in daily life.

02

What they found

The team found no link between the MMR shot and skill loss. Kids who regressed did not get the shot closer to their loss than other kids.

Kids who lost skills did have lower verbal IQ and more tummy problems. Still, the shot was not the trigger.

So, regression is real, but the vaccine is not the cause.

03

How this fits with other research

Baird et al. (2008) counted how many kids lose language in the general autism population. They found about 30 % of narrow autism cases lose words. Jennifer’s team shows those same kids have slightly worse verbal scores, so the two studies line up.

Woo et al. (2007) looked at vaccine-safety reports. Parents sent in more reports about autism when the child had lost skills. That sounds scary, but Jane’s group warned the reports are biased. Jennifer’s clean data back up that warning.

Ben-Itzchak et al. (2020) tracked kids for many years. Higher early verbal skills predicted better teen outcomes. Jennifer’s finding of lower verbal IQ in the regressive group fits right into that long-term picture.

04

Why it matters

You can now tell families the MMR shot does not cause regressive autism. Point them to the clear data instead of scary stories. When you see a child who lost words, check verbal IQ and GI issues, but skip vaccine blame. Use the extra clues to plan language goals and medical referrals right away.

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→ Action — try this Monday

If a parent mentions MMR and regression, show them the Jennifer et al. chart and shift the talk to current language and feeding goals.

02At a glance

Intervention
not applicable
Design
other
Sample size
382
Population
autism spectrum disorder, neurotypical
Finding
not reported

03Original abstract

A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children's early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed.

Journal of autism and developmental disorders, 2006 · doi:10.1007/s10803-005-0070-1