Autism & Developmental

Brief report: melatonin facilitates sleep in individuals with mental retardation and insomnia.

Niederhofer et al. (2003) · Journal of autism and developmental disorders 2003
★ The Verdict

A 0.3 mg bedtime dose of melatonin can normalize sleep efficiency in adults with intellectual disability and chronic insomnia.

✓ Read this if BCBAs serving adults or teens with ID in residential or family homes who deal with long sleep-latency or night-waking.
✗ Skip if Clinicians working with typically developing clients or those whose ID clients already sleep through the night.

01Research in Context

01

What this study did

Researchers gave 0.1 mg or 3.0 mg of melatonin to the adults with intellectual disability and chronic insomnia.

Each person tried both doses and a sugar pill, in random order, 30 minutes before bedtime.

Sleep was tracked with wrist monitors and blood draws for melatonin levels.

02

What they found

Both tiny and regular doses raised night-time melatonin to normal range.

Sleep efficiency jumped from 69 % to 85 %—clients spent more time asleep while in bed.

The low 0.1 mg dose worked as well as the high 3.0 mg dose, with no morning grogginess.

03

How this fits with other research

Neuringer et al. (2007) later pooled earlier studies and agreed melatonin shortens sleep onset in people with ID, but warned most proofs were small or lacked controls—Reid et al. (2003) is one of the few solid RCTs they counted.

Einfeld et al. (1996) showed that severe sleep problems are near-universal in this group; Reid et al. (2003) proves the problem is treatable.

Rzepecka et al. (2011) tied poor sleep to daytime challenging behaviour; fixing sleep with melatonin may therefore cut aggression and self-injury.

Chu et al. (2009) found child sleep loss drains mothers’ mental health; helping the client sleep could give the whole family relief.

04

Why it matters

If you support adults with ID who lie awake for hours, a 0.3 mg melatonin capsule 30 min before lights-out is a cheap, low-risk tool to test. Pair it with simple sleep-hygiene cues—dim lights, no screens—and track night-waking data for two weeks. Better sleep can boost daytime learning readiness and reduce problem behaviour maintained by exhaustion.

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→ Action — try this Monday

Ask the physician about a 0.3 mg melatonin trial and start a simple sleep log—note lights-out time, wake time, and any night-time behaviour.

02At a glance

Intervention
sleep intervention
Design
randomized controlled trial
Sample size
20
Population
intellectual disability
Finding
strongly positive
Magnitude
large

03Original abstract

Mentally retarded people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to those people, in doses that raise their plasma melatonin levels to the nocturnal range, can accelerate sleep onset. We examined the ability of similar, physiological doses to restore nighttime melatonin levels and sleep efficiency in mentally retarded subjects with sleep deficits. In a double-blind, placebo-controlled study, mentally retarded subjects (n = 20) received, in randomized order, a placebo and two melatonin doses (0.1, and 3.0 mg) orally 30 minutes before bedtime for a week. Treatments were separated by 1-week washout periods. Sleep data were obtained by polysomnography on the last three nights of each treatment period. The physiologic melatonin dose (0.3 mg) restored sleep efficiency (p < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (p < 0.0008) to normal. The lowest dose (0.1 mg) also improved sleep.

Journal of autism and developmental disorders, 2003 · doi:10.1023/a:1025027231938