Why do we need sex-balanced studies of autism?
Autism research skews male—recruit equal numbers of girls and boys or keep building an incomplete science.
01Research in Context
What this study did
Nordahl (2023) wrote a position paper. It says autism studies enroll far more boys than girls.
The paper argues this habit hides how autism looks and feels in females.
No new data were collected; the author mapped the problem and told teams to fix it.
What they found
The review shows most autism samples are over 80% male.
Because girls are scarce in studies, we know little about their traits, needs, or outcomes.
Wu says equal numbers of males and females must be recruited in every future project.
How this fits with other research
Hodge et al. (2025) extends the warning. In a Sydney clinic, girls were assessed six months later than boys even when IQ and daily skills were the same. The real-world delay proves the male-heavy lens costs girls time.
Mandy et al. (2012) and Fusar-Poli et al. (2017) supply earlier evidence. Large reviews already showed girls display milder repetitive play and calmer classroom behavior. Wu pulls these facts together and calls the next step: balance the samples.
Szakal et al. (2026) is already answering. Their upcoming meta-analysis will test whether the “extreme male brain” profile is even stronger in autistic girls. The move from Wu’s plea to Cory’s new data shows the field can pivot quickly once sex balance is required.
Why it matters
If your intake roster is mostly boys, pause and ask why. Screen girls who show subtle social stress or sensory issues. Add equal sex enrollment to your next grant or ethics form. Balanced samples give you valid norms, earlier detection for girls, and interventions that fit the whole spectrum.
Want CEUs on This Topic?
The ABA Clubhouse has 60+ free CEUs — live every Wednesday. Ethics, supervision & clinical topics.
Join Free →Add a sex-balanced enrollment target to your next assessment or research plan—aim for 50/50.
02At a glance
03Original abstract
Males are diagnosed with autism much more frequently than females, and most research study samples reflect this male predominance. The result is that autistic females are understudied. There is a critical need to increase our understanding of autistic females, both biologically and clinically. The only way to do this is to recruit sex-balanced cohorts in studies so that similarities and differences between males and females can be evaluated in all autism research studies. The purpose of this commentary is to (1) provide historical context about how females came to be under-represented in all research, not just in the field of autism and (2) learn from other areas of health and medicine about the potentially dire consequences of not studying both sexes, and (3) draw attention to the need to recruit sex-balanced cohorts in autism research, particularly in neuroimaging studies.
Autism research : official journal of the International Society for Autism Research, 2023 · doi:10.1016/B978-0-12-814411-4.00027-5