The nature of covariation between autistic traits and clumsiness: a twin study in a general population sample.
Clumsiness and autistic traits ride on largely the same genetic package in school-age twins.
01Research in Context
What this study did
The team studied 398 twin pairs from the general population.
Parents filled out two short checklists: one on clumsy motor slips and one on autistic-like behaviors.
Using twin statistics, the researchers asked how much of the overlap is genetic.
What they found
Clumsiness and autistic traits shared about two-thirds of their genetic influences.
The link was almost entirely genetic, not because one trait causes the other.
How this fits with other research
Ho et al. (2005) first noticed twin boys score slightly higher on autistic traits than single-born boys.
The new result explains why: the same genes that raise clumsiness can raise sub-threshold autistic traits.
Isaksson et al. (2019) used the same twin trick on mind-reading skills.
They showed the autism–social-cognition link vanishes within pairs, just as clumsiness here is tied to shared genes, not direct causation.
Zubizarreta et al. (2025) later kept the co-twin design but swapped clumsiness for camouflaging stress.
Their mixed findings prove the twin method keeps revealing when family genetics, not the trait itself, drives later outcomes.
Why it matters
If a child shows both clumsy motor moves and borderline autistic behaviors, think shared biology instead of one problem causing the other.
When you see a motor-red flag during assessment, probe social-communication skills too; the same family genes may load on both areas.
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02At a glance
03Original abstract
While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8-17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63.
Journal of autism and developmental disorders, 2011 · doi:10.1007/s10803-011-1199-8