The association between Coffin-Lowry syndrome and psychosis: a family study.

Sivagamasundari et al. (1994) mapped one family with Coffin-Lowry syndrome. They wrote down every member’s health and mind problems. No treatment was tested; they just described what they saw.

Mildly affected women in the family had psychosis with depression. Severely affected men were born totally deaf. The paper tells you to watch for these two problems in your own clients.

Whitehouse et al. (2014) saw the same pattern in adults with 22q11 deletion: genetic syndrome plus ID equals high psychosis risk. Both papers say, “Look past the disability label.”

Kushalnagar et al. (2017) adds a warning: deaf clients who could not talk with parents grow up with eight times more depression. U’s deaf boys may face the same road.

Symons et al. (2005) reminds us that severe ID can hide PTSD; U shows it can also hide psychosis. Same message—different label.

If you serve a client with Coffin-Lowry, add two quick screens. Ask the doctor about hearing tests for boys. Watch girls for sudden mood or thought changes. Early catch means earlier help and less crisis later.