Assessment & Research

Psychophysiological Correlates of Developmental Changes in Healthy and Autistic Boys.

Weismüller et al. (2015) · Journal of autism and developmental disorders 2015
★ The Verdict

MMN offers a painless way to track auditory maturation and spot language risk in school-age boys with or without autism.

✓ Read this if BCBAs doing reassessments for school-age clients with autism.
✗ Skip if Clinicians who only serve toddlers or adults.

01Research in Context

01

What this study did

Weismüller et al. (2015) recorded brain waves while boys with and without autism listened to sounds.

They tracked how a small wave called MMN changed with age.

All boys were between 8 and 18 years old.

02

What they found

MMN grew larger as boys got older.

Bigger MMN linked to better talking and thinking skills.

The wave could not tell which boys had autism and which did not.

03

How this fits with other research

Porter et al. (2008) saw smaller MMN in autistic kids.

The new study shows MMN grows with age, so the early small wave may catch a delay, not a fixed deficit.

Gillespie-Lynch et al. (2019) found only weak links between social skills and most brain measures.

Benjamin’s team shows MMN is one of the few ties that is steady, giving us a clear marker to watch.

04

Why it matters

You can use MMN as a quick, non-verbal check on auditory growth during reassessments.

If the wave is still small in an older child, add language and executive-function goals.

Pair auditory tasks with active attention cues, since automatic brain response alone may not be enough.

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→ Action — try this Monday

Add a short oddball sound game to your next session and note if the child reacts to tone changes—flag flat responses for follow-up.

02At a glance

Intervention
not applicable
Design
case control
Sample size
33
Population
autism spectrum disorder, neurotypical
Finding
mixed

03Original abstract

This study investigated neurodevelopmental changes in sound processing by recording mismatch negativity (MMN) in response to various degrees of sound complexity in 18 mildly to moderately autistic versus 15 healthy boys aged between 6 and 15 years. Autistic boys presented with lower IQ and poor performance on a range of executive and social function measures when compared to their healthy counterparts. We found that MMN in response to duration deviants was less lateralized in the clinical group whereas larger amplitudes correlated with advanced age, thus capturing neurodevelopmental changes. Larger MMN in response to speech-like sound deviants was associated with better verbal fluency and executive function performance, respectively, but did not reliably discriminate the two groups.

Journal of autism and developmental disorders, 2015 · doi:10.1007/s10803-015-2385-x