Assessment & Research

Memory in intellectually matched groups of young participants with 22q11.2 deletion syndrome and those with schizophrenia.

Kravariti et al. (2010) · Research in developmental disabilities 2010
★ The Verdict

Teens with 22q11DS keep verbal memory strength even when other thinking skills lag.

✓ Read this if BCBAs assessing or writing plans for teens with 22q11DS in clinic or school settings.
✗ Skip if Practitioners who work only with adults or purely autism caseloads.

01Research in Context

01

What this study did

Kravariti et al. (2010) compared memory skills in two teen groups.

One group had 22q11.2 deletion syndrome. The other had schizophrenia.

Both groups had the same IQ range so intelligence was held constant.

Kids did verbal and visual memory tests in a single visit.

02

What they found

The 22q11DS group scored much higher on verbal memory tasks.

Visual memory scores were nearly the same for both groups.

Mixed results mean strengths and weaknesses differ by memory type.

03

How this fits with other research

Niklasson et al. (2010) mapped wider thinking problems in 22q11DS. They also found low average IQ and visuo-motor gaps, matching Eugenia’s equal visual memory scores.

Wong et al. (2009) showed teens with 22q11DS struggle with flexible thinking. Poor executive scores linked to later mental-health risk. Together with Eugenia, the picture is: verbal memory can stay strong even when planning skills slip.

Van Den Heuvel et al. (2018) tracked kids for two years. Cognitive scores stayed flat, yet social problems worsened. This seems to clash with Eugenia’s stable visual memory, but Ellen looked at social change over time while Eugenia took one memory snapshot. The studies ask different questions, so no real contradiction exists.

04

Why it matters

If you serve a teen with 22q11DS, expect clear verbal memory but keep an eye on executive and social domains. Use the child’s strong verbal skills to teach coping strategies. Pair words with visuals during instruction to offset weaker spatial memory.

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Start each task with a quick verbal recap; let the client repeat directions aloud to tap their stronger verbal memory.

02At a glance

Intervention
not applicable
Design
quasi experimental
Sample size
44
Population
other
Finding
mixed

03Original abstract

The 22q11.2 deletion syndrome (22qDS) and schizophrenia have genetic and neuropsychological similarities, but are likely to differ in memory profile. Confirming differences in memory function between the two disorders, and identifying their genetic determinants, can help to define genetic subtypes in both syndromes, identify genetic risk factors for the emergence of psychosis, and develop pharmacological interventions for cognitive dysfunction. However, no study has compared memory function between 22qDS and schizophrenia, while indirect comparisons are confounded by marked differences in IQ between the two populations. We compared verbal and visual memory in 29 children and adolescents with 22qDS and 15 intellectually matched youths with schizophrenia using age-appropriate, directly comparable, Wechsler scales. Verbal memory was markedly superior in the 22qDS group by 21 points. There were no group differences in visual memory. The inherently low COMT activity in 22qDS merits investigation as a potential protective factor for verbal memory.

Research in developmental disabilities, 2010 · doi:10.1016/j.ridd.2010.03.003