Assessment & Research

Differential olfactory identification in children with autism and Asperger's disorder: a comparative and longitudinal study.

May et al. (2011) · Journal of autism and developmental disorders 2011
★ The Verdict

A one-nostril smell test can help tell high-functioning autism from Asperger's in verbal kids.

✓ Read this if BCBAs who assess school-age verbal clients with autism spectrum diagnoses.
✗ Skip if Clinicians serving only non-verbal or infants where smell naming is not possible.

01Research in Context

01

What this study did

May et al. (2011) compared how well kids with high-functioning autism and Asperger's disorder could name smells.

They tested each nostril alone and then both together.

The same children came back two years later so the team could see if the pattern stayed the same.

02

What they found

The high-functioning autism group kept failing to name smells when only one nostril was used.

The Asperger's and typical groups did not show this one-sided problem.

The authors say the result points to different brain wiring in the two autism sub-types.

03

How this fits with other research

Bao et al. (2017) later looked at fourteen smell-and-taste studies and also found mixed results across the spectrum, but they noted that naming smells was the task most often impaired.

Legiša et al. (2013) used the same high-functioning autism group and found the kids felt and showed emotion to smells just like peers, yet they could not always tell you what they felt.

Together these papers suggest the nose works fine for detecting and reacting, yet the brain label-maker is weak in high-functioning autism.

04

Why it matters

If you assess a child who can talk well but bombs a simple smell-name test, do not assume poor effort.

The unirhinal failure may flag an autism profile that needs stronger visual or verbal cues during teaching.

Try pairing new foods or hygiene tasks with picture cards instead of relying on the child to tell you what they smell.

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Add a quick smell-ID probe with each nostril to your intake kit and note any one-sided errors.

02At a glance

Intervention
not applicable
Design
other
Population
autism spectrum disorder
Finding
mixed

03Original abstract

Key theories of autism implicate orbitofrontal cortex (OFC) compromise, while olfactory identification (OI) deficits are associated with OFC dysfunction. This study aimed to complete a 5-year follow-up of children with high-functioning autism (HFA) who previously lacked the normal age-OI association; and compare unirhinal-OI in children with HFA, Asperger's disorder (ASP), and controls. While both HFA and controls had improved birhinal-OI at follow-up, reduced OI in some HFA participants suggested OFC deterioration and heterogeneous OFC development. Unirhinal-OI was impaired in HFA but not ASP relative to controls, suggesting orbitofrontal compromise in HFA but integrity in ASP. Differing IQ-OI relationships existed between HFA and ASP. Findings support the hypothesis of separate neurobiological underpinnings in ASP and HFA, specifically differential orbitofrontal functioning.

Journal of autism and developmental disorders, 2011 · doi:10.1007/s10803-010-1101-0