Computerised cognitive testing of individuals with Down's syndrome and Alzheimer's disease.
NeuroTrax gives steady cognitive scores across 18 months in adults with Down syndrome and Alzheimer’s, so you can trust small drops as real warning signs.
01Research in Context
What this study did
Gutman et al. (2016) tracked the same adults with Down syndrome and Alzheimer’s disease for 18 months.
They gave the NeuroTrax computerized battery every few months to see if scores stayed steady.
The goal was to check if the test could reliably spot change when it really happens.
What they found
Memory, executive, verbal, and visuospatial scores did not drift over the year and a half.
The test-retest numbers stayed tight, meaning the battery is stable for long-term use.
How this fits with other research
Prasher et al. (2004) already showed the 15-item ABDQ caregiver quiz screens dementia with 92 % accuracy. Michael’s team moves the field forward by proving a computerized battery can also stay steady over time.
Moya et al. (2022) used a French recall test to separate adults with Down syndrome plus Alzheimer’s from those without. Both studies use small case series, but different tools—mCRT versus NeuroTrax—giving clinicians more than one option.
Waldron et al. (2023) warn that most inhibitory-control tasks flop in youth with Down syndrome. Michael’s work counters that concern for adults by showing global cognitive scores that do hold up.
Why it matters
You now have evidence that NeuroTrax won’t give you fake decline or fake gain across 18 months. Use it to track adults with Down syndrome and suspected dementia without second-guessing the numbers.
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02At a glance
03Original abstract
BACKGROUND: Although Alzheimer's disease neuropathology is present by age 40 years, in Down's syndrome, ante-mortem diagnosis is difficult. No standard for cognitive assessment is well established or easy to administer. METHOD: We used a simple, widely available computerised test (NeuroTrax Moderate to Severe Impairment Assessment Battery, Mindstreams, Newark, NJ) to evaluate 14 patients in this population. Orientation, memory, executive function, verbal function and visual spatial function were evaluated every 6 months for 18 months. RESULTS: Mean scaled scores in this longitudinal study were evaluated with repeated measures analysis of variance. Memory, executive function, verbal function and visual spatial function scores did not significantly change. There was no significant depression or anxiety on self-reported measures. CONCLUSIONS: Reproducibility of test results supports the reliability of this battery to quantify function and prospectively follow performance in this population over an 18-month period.
Journal of intellectual disability research : JIDR, 2016 · doi:10.1111/jir.12227