Assessment & Research

Can standard measures identify subclinical markers of autism?

Ozonoff et al. (1993) · Journal of autism and developmental disorders 1993
★ The Verdict

Classic theory-of-mind tasks miss subtle autism-risk markers—swap in executive-function checks when you screen unaffected siblings.

✓ Read this if BCBAs who conduct intake assessments for families with more than one child on the spectrum.
✗ Skip if Clinicians only working with single, already-diagnosed clients and no sibling data.

01Research in Context

01

What this study did

The team gave classic autism tests to siblings of diagnosed children. They wanted to see if the tests could spot hidden thinking problems in kids who had no diagnosis.

They used two kinds of tasks. One checked executive function—skills like planning and shifting focus. The other checked theory of mind—understanding what others think.

02

What they found

Executive-function tasks showed small but real group differences. The authors said this might be a 'subclinical marker' of autism risk.

Theory-of-mind tasks found nothing. The tools were too easy or too blunt to pick up subtle social-cognitive gaps.

03

How this fits with other research

Ko et al. (2024) later showed the same kind of executive gaps explain over half of autism-symptom variance in preschoolers. Their newer BRIEF-P scale caught what the 1993 kit missed.

Green et al. (2020) sharpened the picture. They found language-based executive skills, not general social training, predict who fails advanced faux-pas tests in the broader autism phenotype. That backs the 1993 hunch that standard ToM tasks lack sensitivity.

Kouklari et al. (2018) ran direct EF tests on 8- to 12-year-olds. Working memory predicted theory-of-mind scores, but EF did not predict everyday social talk. Together the studies say: use targeted EF tasks, skip broad ToM checklists.

04

Why it matters

If you test siblings or parents during an intake, swap out old false-belief stories for brief executive-function probes like the BRIEF-P or a quick card-sort. A low score won't give a diagnosis, but it flags families who may need closer developmental watch or parent coaching on planning and flexibility skills.

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Add one brief EF probe (e.g., BRIEF-P or a five-trial card-sort) to your sibling intake packet.

02At a glance

Intervention
not applicable
Design
quasi experimental
Population
not specified
Finding
mixed

03Original abstract

This study compared the executive function and theory-of-mind abilities of siblings of autistic individuals to those of siblings of learning-disabled controls. Three different analyses of the dependent measures provided convergent support for a potential subclinical marker in the executive function domain. No group differences in theory-of-mind abilities were found. However, power analyses revealed that the measures employed in this study, which are typically used with autistic individuals, were not sufficiently sensitive to detect any group differences that might exist in "unaffected" family members. Suggestions for future research are provided, including the need to develop more sensitive tasks that produce larger effects and measure more elementary cognitive operations.

Journal of autism and developmental disorders, 1993 · doi:10.1007/BF01046049