Brief report: maternal smoking during pregnancy and autism spectrum disorders.
After family income and education are counted, maternal smoking during pregnancy does not increase autism risk.
01Research in Context
What this study did
K et al. looked at every child born in Sweden from 1984-2003.
They asked: do moms who smoke while pregnant have more kids later diagnosed with autism?
To answer, they matched each child with autism to five similar kids without autism.
Then they compared how many moms in each group had smoked.
What they found
At first glance, smoking moms seemed to have more kids with autism.
But once the team factored in parents’ education, jobs, and income, the link vanished.
Bottom line: smoking itself did not raise autism odds after family life-stress was counted.
How this fits with other research
Tioleco et al. (2021) pooled 36 studies and found mild infections during pregnancy can slightly bump autism risk.
That review did NOT flag smoking as a clear risk, backing the null finding here.
Duker et al. (1991) saw small birth hiccups in bright kids with autism, but also said those hiccups matter little—echoing the “don’t blame smoking” message.
Zhao et al. (2024) used the same kind of big-database check and found unintended pregnancy plus low folic acid raised risk; again, smoking sat on the sidelines.
Why it matters
You can reassure worried parents: mom’s past smoking is unlikely to have caused their child’s autism.
Shift focus to factors the data do support—like treating maternal infections or promoting folic acid.
When writing reports, leave smoking off the autism risk list and zero-in on supports that truly help.
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02At a glance
03Original abstract
Prenatal exposure to tobacco smoke is suggested as a potential risk factor for autism spectrum disorders (ASD). Previous epidemiological studies of this topic have yielded mixed findings. We performed a case-control study of 3,958 ASD cases and 38,983 controls nested in a large register-based cohort in Sweden. ASD case status was measured using a multisource case ascertainment system. In adjusted results, we found that maternal smoking during pregnancy is not associated with increased risk of ASD regardless of presence or absence of comorbid intellectual disability. Apparent associations were attributable to confounding by sociodemographic characteristics of parents such as education, income, and occupation.
Journal of autism and developmental disorders, 2012 · doi:10.1007/s10803-011-1425-4