Assessment & Research

Antiepileptic drugs with mood stabilizing properties and their relation with psychotropic drug use in institutionalized epilepsy patients with intellectual disability.

Leunissen et al. (2011) · Research in developmental disabilities 2011
★ The Verdict

In group homes, higher doses of mood-stabilizing seizure drugs mean fewer extra psychotropics for adults with ID and epilepsy.

✓ Read this if BCBAs working with adults who have both intellectual disability and epilepsy in residential settings.
✗ Skip if Clinicians serving only children or people without seizure disorders.

01Research in Context

01

What this study did

The team looked at 246 adults living in UK homes for people with intellectual disability and epilepsy. They counted how many mood-stabilizing seizure drugs each person took. Then they counted prescriptions for extra psychotropics like antipsychotics or sleeping pills.

The study ran like a snapshot. No one changed meds. Staff just pulled pharmacy records and compared numbers.

02

What they found

People on higher doses of mood-stabilizing seizure drugs needed fewer other psychotropics. The link held for carbamazepine, valproate, and lamotrigine.

In plain words, maximizing the seizure drug that also steadies mood cut the need for extra calming pills.

03

How this fits with other research

Arshad et al. (2011) looked at the same year and saw the opposite. In their clinic, adults with ID plus epilepsy carried fewer psychiatric labels than those without epilepsy. The gap is about sampling. F et al. watched everyone in the home. Saadia only saw people sent to a mental-health clinic.

Scheifes et al. (2016) and de Kuijper et al. (2013) show why fewer psychotropics matter. They found that 84% of adults with ID had side-effects from these drugs. Problems ranged from weight gain to tremors. F et al. give a way to dodge that harm by using seizure meds that already stabilize mood.

Rose et al. (2000) mapped UK psychotropic use a decade earlier. They showed most pills were given for behavior, not illness. F et al. update that picture by adding epilepsy care as a lever to reduce those behavior-driven scripts.

04

Why it matters

If you serve adults with both ID and epilepsy, check their seizure drug list first. Ask the doctor if the dose gives mood cover. A small upward tweak might let you drop an antipsychotic or sleep aid and spare side-effects. Always pair any change with data on behavior and seizures.

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Chart each client's mood-stabilizing AED dose and flag anyone on added antipsychotics for med-review.

02At a glance

Intervention
not applicable
Design
other
Sample size
246
Population
intellectual disability
Finding
positive

03Original abstract

A large number of patients with epilepsy and intellectual disability take medication, amongst which antiepileptic and psychotropic drugs, often simultaneously. Certain antiepileptic drugs have mood-stabilizing properties, e.g. carbamazepine, valproic acid and lamotrigine. The aim of this study was to investigate whether the use of these mood-stabilizers is associated with a different use of psychotropic drugs in a population of institutionalized epilepsy patients with intellectual disability. We performed a retrospective, cohort study of adults with intellectual disability and epilepsy at the long-stay department of an epilepsy centre in The Netherlands. 246 residents were included. In patients using lamotrigine we found a statistically significant lower use of antidepressants. We also found significant less prescriptions of anxiolytics in patients using AEDs with mood-stabilizing properties (carbamazepine, valproic acid and lamotrigine). When considering the effect of gender, we found that male patients took significantly more antipsychotics. Most important, we found an inverse relation between the drug load of carbamazepine and/or valproic acid and/or lamotrigine and the use of psychotropic drugs. In a population of institutionalized epilepsy patients with intellectual disability, higher drug loads of mood-stabilizing antiepileptic drugs correspond with less use of psychotropic drugs.

Research in developmental disabilities, 2011 · doi:10.1016/j.ridd.2011.06.007