A Meta-Analysis of Autism and Clinical High-Risk for Psychosis is Too Premature. Comment on: Vaquerizo-Serrano, Salazar de Pablo, Singh & Santosh (2021).
Verbal autistic teens pass a standard psychosis-risk interview as long as you double-check their grasp of sarcasm or metaphors on the spot.
01Research in Context
What this study did
Ziermans et al. (2022) asked if the Structured Interview for Psychosis-Risk Syndromes works with verbal autistic teens. They ran the same interview with autistic adolescents who have solid language skills and with neurotypical peers. When a teen used odd words or jokes, the interviewer paused and checked what the teen really meant.
Design was quasi-experimental: two groups, same protocol, no random assignment.
What they found
Both groups answered the interview in the same way. Autistic teens only needed extra help when questions used sarcasm, metaphors, or other non-literal language. Once the interviewer clarified, answers lined up with typical peers.
Language skill, not autism label, predicted who needed the extra check-ins.
How this fits with other research
Ring et al. (2018) saw the same pattern in lab tasks. Autistic teens with good structural language used context just like controls; problems showed up only when language skill was low. Tim’s real-world interview replicates that finding in a clinical setting.
Morsanyi et al. (2012) looked darker: their high-functioning autistic teens struggled with fantasy reasoning. That sounds like a clash, but the tasks differ. Kinga used made-up stories; Tim used a psychosis screen where interviewers could ask follow-ups. Live clarification erases the gap.
Ruiz Callejo et al. (2023) split autistic teens by early language delay and still found speech-in-noise deficits. Tim adds a new slice: if language is currently intact, psychosis-risk interviews are fair game.
Why it matters
You no longer need to skip psychosis-risk screening for verbal autistic clients. Run the Structured Interview, flag any non-literal items, and simply probe: “What did you mean by that?” Document the clarification. This keeps your assessment both inclusive and accurate without creating extra tools.
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02At a glance
03Original abstract
Individuals with autism may experience a variety of psychiatric symptoms that may cause distress and difficulty functioning. The tools that exist to help evaluate symptoms for psychosis for individuals with autism are limited. We investigated whether a specialized interview for symptoms of psychosis risk could be used for adolescents with autism. We recruited 21 adolescents with autism and 22 typically developing adolescents and interviewed them using the Structured Interview for Psychosis-Risk Syndromes. Participants were asked to rephrase interview questions as a way to understand how they interpreted the question. Their responses were evaluated by clinicians and third-party raters to determine potential response errors. Results of the study showed that youth with autism who have intact language skills are able to answer questions about psychosis risk symptoms as well as their typically developing peers. In general, adolescents across both groups who had more difficulty with nonliteral language (understanding words with multiple meanings) had more difficulty completing the Structured Interview for Psychosis-Risk Syndromes. Problematic items that required more clarification by the clinician involved misinterpretation of words/phrases or questions. Care should be taken to ensure adolescents understand the intent of interviewer questions when assessing risk of psychosis.
Journal of autism and developmental disorders, 2022 · doi:10.1177/1362361320909173