A Comparison Between Two Screening Approaches for ASD Among Toddlers in Israel.
M-CHAT/F grabs 20% more autism cases than broad growth checks without raising false alarms in Israeli city clinics.
01Research in Context
What this study did
Kerub et al. (2020) ran toddler clinics in Israel. They gave half the families the M-CHAT/F. They gave the other half a broad growth survey. Both groups were 18-24 months old.
Staff then sent all kids for full autism check-ups. They counted who really had ASD. The goal: see which quick paper caught more true cases.
What they found
M-CHAT/F spotted seven out of every ten kids later diagnosed with ASD. The broad growth survey caught only five out of ten. Both screens almost never flagged typical kids as sick.
In short, the autism tool found 20% more cases with almost no extra false alarms.
How this fits with other research
Berkovits et al. (2014) in the U.S. saw the same win: M-CHAT beat the broad PEDS survey. The pattern repeats across countries.
Scarpa et al. (2013) looks like a clash. In poor rural America M-CHAT gave many false positives. The gap is real but explainable: language trouble and low parent education raise error rates. Israel's urban clinics had fewer of those hurdles.
Leung et al. (2014) found high screen-positive rates in Hispanic clinics. Again, culture and language, not the tool itself, drove the numbers. Same test, different context.
Why it matters
If you screen in low-risk, well-educated, urban clinics, swap in M-CHAT/F and you will catch more ASD early. If you work with rural, low-SES, or non-English families, plan extra follow-up calls and interpreter help to keep false positives down. One size does not fit all.
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02At a glance
03Original abstract
Systematic screening of autism spectrum disorder (ASD) can improve early diagnosis of ASD. We compared the efficacy of two ASD screening methods, the Global Developmental Screening (GDS), and the Modified Checklist for Autism in Toddlers-Revised, with Follow-Up (M-CHAT/F) in 1591 toddlers of ages 18-36 months from 35 government-funded clinics in south Israel. The M-CHAT/F performed better than the GDS in detecting toddlers with ASD (sensitivity: 70.0% vs. 50.0%, and specificity: 98.2% vs. 96.6% respectively). Both methods had an equivalent performance in detecting other forms of developmental delays (sensitivity = 63%; and specificity ~ 98%). In addition, remarkable inter-nurse variation was observed in the GDS referral decisions. Thus, employment of the M-CHAT/F in the Israeli health system may improve early detection of ASD among toddlers.
Journal of autism and developmental disorders, 2020 · doi:10.1007/s10803-018-3711-x