A Preliminary Examination of Acceptance and Commitment Therapy Versus Exposure and Response Prevention for Patients with Obsessive-Compulsive Disorder on an Optimal Dose of SSRIs: A Randomized Controlled Trial in Iran.
Twelve weeks of ACT or ERP added to steady SSRI medication trims OCD symptoms and, for ACT, psychological inflexibility in Iranian adults.
01Research in Context
What this study did
Researchers in Iran split adults with OCD into three groups. All stayed on their usual SSRI pills. One group added twelve weekly ACT sessions. Another added twelve weekly ERP sessions. The third kept pills only.
Doctors rated OCD severity before and after the 12-week program. They also checked psychological inflexibility — how stuck the person felt when urges showed up.
What they found
Both ACT plus SSRI and ERP plus SSRI cut OCD symptoms more than pills alone. ACT also lowered psychological inflexibility, while ERP did not.
The gains were modest but clear. The study was small, yet the pattern held for every participant who received the extra therapy.
How this fits with other research
Lappalainen et al. (2015) showed web-based ACT alone can slash depression with almost no coach contact. Mehdi’s team now shows ACT plus SSRI also helps OCD in face-to-face format. Same core therapy, new setting and diagnosis.
Wetterneck et al. (2006) used ERP in a single-case design and saw tics disappear fast, but some returned within three months. Mehdi’s RCT finds ERP still works when paired with SSRI, giving longer hope.
Arwert et al. (2020) tracked kids who over-predicted ERP distress and found they improved quickest. Mehdi did not measure expectancies, so we don’t know if the same speed boost applies to adults.
Why it matters
If your adult client is stable on an SSRI but still stuck in rituals, adding either ACT or ERP can nudge symptoms down. ACT gives the bonus of loosening rule-governed behavior, so consider it when rigidity is high. Start with one session per week for twelve weeks, measure OCD severity each month, and watch for drops in both compulsions and inflexibility.
Want CEUs on This Topic?
The ABA Clubhouse has 60+ free CEUs — live every Wednesday. Ethics, supervision & clinical topics.
Join Free →Pick one ACT value-based exposure task and run it during the next session while the client stays on their current SSRI dose.
02At a glance
03Original abstract
This study compared the effects of adding acceptance and commitment therapy (ACT) or exposure and response prevention (ERP) to adults diagnosed with obsessive compulsive disorder (OCD) already on an optimal and stable dose of selective serotonin reuptake inhibitors (SSRIs). Forty adults on SSRIs who were diagnosed with OCD participated in a randomized controlled trial in Iran of 12 individual weekly sessions of either ACT+SSRI, ERP+SSRI, or continued SSRI only. The results showed significant reductions in OCD symptom severity in ACT+SSRI and ERP+SSRI conditions at posttreatment with significantly greater reductions in both conditions compared to SSRI-only at follow-up. Additionally, psychological inflexibility and use of thought control strategies significantly decreased in the ACT+SSRI condition at posttreatment and follow-up compared to the ERP+SSRI and SSRI conditions. Both conditions led to decreases in perceived importance of stop signals. Results provide cross-cultural support for the treatment of OCD using ACT and ERP as adjuncts to SSRI and modest process of change differences between ACT and ERP. Future directions and study limitations are discussed.
Behavior modification, 2022 · doi:10.1177/0145445520982977