Two boys with 47, XXY and autism.

Doctors wrote up two boys who had both autism and Klinefelter syndrome (47, XXY).

They listed each boy’s words, seizure tests, and medicines tried.

Both boys talked late and had odd EEGs, but no seizures yet.

Anti-seizure drugs did not help the EEGs.

Gotham et al. (2015) saw more real seizures in pre-term autistic boys. L et al.’s boys were full-term and only had EEG spikes. The risk looks tied to birth age, not a clash in data.

Souza et al. (2023) widen the picture: autistic girls actually show more epilepsy than boys. So EEG checks matter for both sexes, even though L et al. only had males.

Flapper et al. (2013) review shows fragile X, Rett, and other gene syndromes often bring seizures. Klinefelter now joins that watch list.

If you assess an autistic boy with slow language, ask about sex-chromosome history and order a baseline EEG. Early spikes can guide sleep, medication, and family training before true seizures start.