Refractive Status and Amblyopia Risk Factors in Chinese Children with Autism Spectrum Disorder.
Crossed eyes are ten times more common in young Chinese children with autism—screen every child with ASD early.
01Research in Context
What this study did
Wang et al. (2018) compared eyes of Chinese preschool and early-grade children with autism to same-age peers without autism.
An eye doctor gave every child a full vision exam. They looked for lazy-eye risk factors like crossed eyes (strabismus) and blurry focus (refractive error).
What they found
Sixteen of every 100 kids with autism had crossed eyes. Only one or two of every 100 typical kids did.
The large gap means children with autism need vision checks early and often.
How this fits with other research
Wu et al. (2023) later saw the same pattern in U.S. youths aged 3-18. They also found higher lazy-eye and refractive-error odds, proving the risk is not just Chinese kids or preschoolers.
Milne et al. (2009) gave the first clue: British kids with autism showed weak eye teaming. Jiaxing’s team now shows the clinical fallout—many crossed eyes—building on that early warning.
Laugeson et al. (2014) tested the same Chinese preschool group and found normal sharp vision. Together the papers say: eyes look clear, but they may still be crossed, so always test alignment, not just the eye chart.
Why it matters
Crossed eyes can drop depth perception and spawn lazy eye. Glasses, patches, or surgery work best when started young. Add a quick cover test and light reflex check to your intake for every child with autism. If either looks off, refer to an optometrist or ophthalmologist the same week.
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02At a glance
03Original abstract
Amblyopia risk factors in children with autism spectrum disorders (ASD) are usually hard to detect in early childhood due to poor cooperation and has not been reported in the Chinese population. We screened 168 Chinese children with ASD, aged between 3 and 8 years, and 264 age-matched neurotypical children with Spot photoscreener and basic ophthalmologic examinations. Children with ASD were found to have normal refractive status but significantly higher incidence of strabismus (16.1%), compared with control children (1.5%) (p < 0.01). Most of the cases of strabismus found in children with ASD were classified as esodeviation. Strabismus in children with ASD should be considered more seriously as an amblyopia risk factor by ophthalmologists and other healthcare professionals.
Journal of autism and developmental disorders, 2018 · doi:10.1007/s10803-017-3387-7