Oral human immunoglobulin for children with autism and gastrointestinal dysfunction: a prospective, open-label study.

Doctors gave children with autism a daily pill of human antibodies. The pill is called oral immunoglobulin.

All children also had chronic stomach pain or diarrhea. The team watched for eight weeks.

No control group was used. Parents and doctors kept notes on gut and behavior changes.

Half of the children had better stools and less pain. Parents said the kids talked and played more.

No serious side effects were seen. The pill helped some, but not all, children.

Shirotani et al. (2026) later used a gut-bug enema instead of pills. Their 2026 study got bigger, longer-lasting gains, but both teams link gut health to autism behavior.

Wong et al. (2024) tried a blood infusion. Their results were weaker, showing that not every biologic works the same.

Morris et al. (1990) and Rimmer et al. (1995) tested other oral biologics years earlier. Small positive signals appeared then too, building a line of biologic add-ons for autism.

You now have a low-risk option to discuss with medical teammates. If a client has GI pain and parents ask about supplements, you can share that antibodies helped half of kids in one open study. Track stool logs and behavior data if a doctor tries it, so your ABA team can spot real changes from gut treatment.