Medical disorders among inpatients with autism in Denmark according to ICD-8: a nationwide register-based study.
In a full chart review of Danish inpatients, autism was tied only to birth defects, not to a broad load of other medical problems.
01Research in Context
What this study did
Danish doctors read every hospital chart for 244 inpatients who had an autism code. They wrote down any extra medical diagnoses listed in the charts.
Next they picked 244 kids without autism who were the same age and sex. They compared how often each group had other medical problems.
What they found
Only one problem showed up more in the autism group: congenital malformations. These are birth defects like heart holes or cleft palate.
All other medical disorders stayed at the same low rate in both groups. Only about 12 out of every 100 kids with autism had any extra medical diagnosis at all.
How this fits with other research
Pan et al. (2021) pooled 97 studies and found lots of neurological problems in autism. Their big picture seems to clash with the Danish result. The gap is method: Pei-Yin counted epilepsy, migraine, and macrocephaly that show up later, while the Danish study only looked at hospital-chart diagnoses that were already written down.
Kielinen et al. (2004) did almost the same chart review in a different country and got the same 12 percent rate. Two matching numbers from two registries make the low rate look real.
Sparaci et al. (2015) went deeper into birth defects and still found the same link. They showed the risk is strongest when autism and intellectual disability occur together.
Why it matters
You can relax a little. Most kids with autism do not carry a hidden list of serious medical illnesses. Still, keep an eye out for congenital malformations, especially in clients who also have intellectual disability. When you see them, mention the higher autism risk to the medical team and document any follow-up plans.
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02At a glance
03Original abstract
Possible associations between autism and specific medical disorders have been suggested, and this could be of relevance in the clinical examination and treatment of patients and may help to identify factors involved in the etiology or pathophysiology of autism. Two population-based Danish registers were used to investigate the occurrence of medical disorders in patients with autism according to ICD-8 and in a matched control sample. A total of 29 of the 244 patients (11.9%) diagnosed with autism had one or more medical disorders. In contrast to previous studies, we did not find an increased occurrence of almost any medical disorders. A highly significant increased frequency of congenital malformations was found, which may indicate abnormalities in embryogenesis in the etiology of autism.
Journal of autism and developmental disorders, 2002 · doi:10.1023/a:1014840622023