Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder.
One in twenty young children and almost one in five teens with autism are on atypical antipsychotics, mostly without strong RCT backing.
01Research in Context
What this study did
The team mailed short surveys to families of children with autism. They asked if the child takes any atypical antipsychotics such as risperidone or aripiprazole.
Parents also checked boxes for age, other medicines, and medical problems. The answers gave a snapshot of who gets these drugs in the United States.
What they found
Among kids aged 2–11, about 5 percent were on an antipsychotic. The rate jumped to 18 percent for teens aged 12–17.
Older age and mixing several psychotropics went hand-in-hand with antipsychotic use.
How this fits with other research
Hudson et al. (2012) reviewed 33 drug trials and remind us that only two antipsychotics have strong evidence for autism. Their paper sits under the new survey like a safety label—prevalence is rising even though proof is thin.
Smith et al. (2010) saw the same climb six years earlier. Their national registry showed one in three kids with autism took some psychotropic. Deserno et al. (2017) narrow the lens to antipsychotics and still find the same age jump, so the trend is holding.
Memari et al. (2012) looked at Iranian pupils and found an eye-popping 80 percent on psychotropics, mostly antipsychotics. The huge gap looks like a contradiction, but the Iranian sample came from specialized schools and had severe behavior problems. Same drug class, different severity filter.
Why it matters
You now have hard numbers to share with families at plan-of-care meetings. If a teen is already on two or more psychoactive drugs, pause and ask why each pill is there. Use the Hudson et al. (2012) review to steer the talk toward evidence-based choices and side-effect checks.
Want CEUs on This Topic?
The ABA Clubhouse has 60+ free CEUs — live every Wednesday. Ethics, supervision & clinical topics.
Join Free →Open the current med list, flag any teen on two-plus psychotropics, and schedule a team review using the Matthew et al. evidence table.
02At a glance
03Original abstract
This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2-11 (n = 4749) and those 12-17 (n = 401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use. Among older children, only older age was associated with antipsychotic use. In at least one age group, antipsychotic medication use was also related to behaviour, family and occupational therapy, public insurance, site region, externalizing problems, body mass index, and sleep and gastrointestinal problems.
Journal of autism and developmental disorders, 2017 · doi:10.1007/s10803-017-3058-8