Increased Risk of Atopic Diseases in the Siblings of Patients with Autism Spectrum Disorder: A Nationwide Population-Based Cohort Study.
Brothers and sisters of children with autism run a clear, across-the-board higher risk for asthma, eczema, and other allergic diseases.
01Research in Context
What this study did
Dai et al. (2019) used a national health registry to track brothers and sisters of children with autism.
They compared how many of these siblings got asthma, eczema, hay fever, and eye allergies to matched kids without an autistic brother or sister.
What they found
Siblings of children with autism had clearly higher odds of every allergy-related illness studied.
The risk stayed high for asthma, eczema, allergic runny nose, and allergic pink eye.
How this fits with other research
Kotey et al. (2014) had already shown autistic kids themselves get asthma about one-third more often.
Ying-Xiu extends that picture by showing the same pattern holds for their brothers and sisters and adds three more allergy types.
Earlier papers such as Orsmond et al. (2009) and Perez et al. (2015) warned that siblings face more anxiety or mood trouble.
The new study does not contradict those findings; it simply maps a different kind of risk—medical instead of emotional.
Why it matters
If you serve a family with autism, flag the siblings for possible asthma, eczema, and allergy symptoms.
Early screening can shorten clinic visits, cut missed school days, and keep the whole family breathing and sleeping better.
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02At a glance
03Original abstract
Several studies have shown a strong association between atopic diseases and autism spectrum disorder (ASD). However, the risk of atopic diseases in individuals having ASD-affected siblings has never been investigated. This nationwide population-based cohort study included 2762 individuals with ASD-affected siblings and 11,048 controls. Diagnoses of atopic diseases, including asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis, were ascertained from 1996 or the birth data to the end of 2011. Individuals with ASD-affected siblings had a higher risk for asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and multiple atopic diseases compared with controls. In conclusion, individuals with ASD-affected siblings were more likely than were the controls to develop atopic diseases, suggesting shared familial mechanisms underlying the two conditions.
Journal of autism and developmental disorders, 2019 · doi:10.1007/s10803-019-04184-w