Autism & Developmental

Increased Risk of Atopic Diseases in the Siblings of Patients with Autism Spectrum Disorder: A Nationwide Population-Based Cohort Study.

Dai et al. (2019) · Journal of autism and developmental disorders 2019
★ The Verdict

Brothers and sisters of children with autism run a clear, across-the-board higher risk for asthma, eczema, and other allergic diseases.

✓ Read this if BCBAs who complete intake assessments or run parent-training sessions in clinic, school, or home programs.
✗ Skip if Practitioners working only with adult clients or in settings without medical screening duties.

01Research in Context

01

What this study did

Dai et al. (2019) used a national health registry to track brothers and sisters of children with autism.

They compared how many of these siblings got asthma, eczema, hay fever, and eye allergies to matched kids without an autistic brother or sister.

02

What they found

Siblings of children with autism had clearly higher odds of every allergy-related illness studied.

The risk stayed high for asthma, eczema, allergic runny nose, and allergic pink eye.

03

How this fits with other research

Kotey et al. (2014) had already shown autistic kids themselves get asthma about one-third more often.

Ying-Xiu extends that picture by showing the same pattern holds for their brothers and sisters and adds three more allergy types.

Earlier papers such as Orsmond et al. (2009) and Perez et al. (2015) warned that siblings face more anxiety or mood trouble.

The new study does not contradict those findings; it simply maps a different kind of risk—medical instead of emotional.

04

Why it matters

If you serve a family with autism, flag the siblings for possible asthma, eczema, and allergy symptoms.

Early screening can shorten clinic visits, cut missed school days, and keep the whole family breathing and sleeping better.

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Add one quick question to your caregiver interview: 'Any asthma, eczema, or allergy symptoms in siblings?' and note yes answers for pediatrician follow-up.

02At a glance

Intervention
not applicable
Design
other
Sample size
13810
Population
autism spectrum disorder
Finding
positive

03Original abstract

Several studies have shown a strong association between atopic diseases and autism spectrum disorder (ASD). However, the risk of atopic diseases in individuals having ASD-affected siblings has never been investigated. This nationwide population-based cohort study included 2762 individuals with ASD-affected siblings and 11,048 controls. Diagnoses of atopic diseases, including asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis, were ascertained from 1996 or the birth data to the end of 2011. Individuals with ASD-affected siblings had a higher risk for asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and multiple atopic diseases compared with controls. In conclusion, individuals with ASD-affected siblings were more likely than were the controls to develop atopic diseases, suggesting shared familial mechanisms underlying the two conditions.

Journal of autism and developmental disorders, 2019 · doi:10.1007/s10803-019-04184-w