Autism & Developmental

Brief Report: Plasma Leptin and Mealtime Feeding Behaviors Among Children with Autism Spectrum Disorder: A Pilot Study.

Dhaliwal et al. (2023) · Journal of autism and developmental disorders 2023
★ The Verdict

Heavier autistic kids show both higher leptin and worse mealtime behaviors—check both if weight is up.

✓ Read this if BCBAs treating autistic children with feeding issues in clinic or home settings.
✗ Skip if Practitioners working only with normal-weight or adult clients.

01Research in Context

01

What this study did

Doctors took a small blood sample from autistic children. They checked how much leptin each child had. Leptin is a hormone that tells the brain when the stomach is full.

Parents also filled out a short checklist about mealtime behaviors. Kids were grouped by weight: normal, overweight, or obese.

02

What they found

Overweight and obese autistic children had higher leptin levels. The same heavy kids also scored worse on the mealtime behavior checklist. Normal-weight kids had lower leptin and fewer food battles.

03

How this fits with other research

Milane et al. (2025) show the BAMBI checklist is the top tool for measuring mealtime problems in autism. Scior et al. (2023) likely used BAMBI, so their finding rests on solid ground.

Shmaya et al. (2017) found sensory issues predict mealtime struggles, but not nutrition gaps. K et al. add weight and leptin as new predictors. Together, the two studies say: check both sensory profile and weight status when feeding is hard.

Welsh et al. (2019) warn that weight talk can upset autistic kids. K et al. give a medical reason to bring it up anyway—high leptin may signal bigger behavior issues. Use gentle words and the data together.

04

Why it matters

If an autistic client is heavy, you now have two quick screens: leptin blood level and a BAMBI checklist. High scores on either flag tougher mealtimes ahead. Share the leptin number with the pediatrician and start behavior skills training early. This pairing keeps you focused on behavior while the doctor watches metabolism.

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Add weight status and BAMBI score to your intake form; flag any overweight child for combined medical-behavior planning.

02At a glance

Intervention
not applicable
Design
case series
Sample size
21
Population
autism spectrum disorder
Finding
positive
Magnitude
small

03Original abstract

We examined the relationship between weight status, appetite regulating hormones, and mealtime behaviors among children, (5-12 years old), diagnosed with Autism Spectrum Disorder (ASD) in a cross-sectional study. All (N = 21) completed anthropometry measurements and (n = 18) provided blood samples for hormone analysis. Mealtime behavior, dietary, physical activity, puberty stage, and social impairment data were collected. Under fasting conditions, overweight/obese (OWOB) participants, (n = 6), had higher leptin concentrations (p < 0.02) and more feeding challenges (p < 0.05) than normal weight (n = 15). Higher leptin levels and disruptions in mealtime behaviors may exist among OWOB children in this study. Future longitudinal studies that examine appetite regulating hormones and mealtime behaviors may inform our understanding of the role of these markers in the development of obesity in ASD.

Journal of autism and developmental disorders, 2023 · doi:10.1016/j.jand.2020.06.015