Autism & Developmental

Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study.

Aran et al. (2019) · Journal of autism and developmental disorders 2019
★ The Verdict

CBD-rich cannabis calmed severe behavior in most kids with autism, yet parent-training programs already do the same without side-effects.

✓ Read this if BCBAs working with children with autism who have daily meltdowns or aggression.
✗ Skip if Practitioners serving adults or clients without severe behavior.

01Research in Context

01

What this study did

Doctors looked back at charts of 60 children with autism and severe behavior problems. All kids had taken cannabis oil rich in CBD for at least a month. Staff rated each child’s behavior outbreaks before and after the oil.

02

What they found

Six out of ten children were rated “much” or “very much” better. Parents and doctors noticed fewer meltdowns and calmer days. The team says a real controlled trial is now worth doing.

03

How this fits with other research

Burrell et al. (2025) show parent training also cuts disruptive behavior in autism. Their meta-analysis gives the same target—behavior outbreaks—but uses coaching instead of cannabis. Bearss et al. (2013) ran a small parent-training case series like this one and saw a 54 % drop in irritability. The CBD data line up: both approaches calm kids, one with pills, one with skills. No clash exists; the tools simply differ.

04

Why it matters

You now have two parent-friendly paths for severe behavior. If families want a drug-free route, start parent training—its evidence is stronger. If behavior is dangerous and meds are on the table, CBD oil looks hopeful but still needs trials. Track baseline meltdowns for two weeks before any change so you can spot real gains.

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Start a two-week baseline count of meltdowns before recommending any new intervention.

02At a glance

Intervention
other
Design
case series
Sample size
60
Population
autism spectrum disorder
Finding
positive
Magnitude
medium

03Original abstract

Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD.

Journal of autism and developmental disorders, 2019 · doi:10.1007/s10803-018-3808-2