Association of Autism Spectrum Disorders and Inflammatory Bowel Disease.
Autism and inflammatory bowel disease travel together—track bowel health to protect learning gains.
01Research in Context
What this study did
Lee et al. (2018) looked at medical records of kids with autism and matched peers. They checked how many in each group had Crohn’s disease or ulcerative colitis. The design was a simple case-control review pulled from large health databases.
What they found
Kids with autism were more likely to meet full criteria for both Crohn’s and colitis. The link stayed strong after basic matching for age and sex. In plain words, IBD is not rare in autism; it shows up more than clinicians expect.
How this fits with other research
Kaiser et al. (2022) pooled over 11 million kids and found the same bump in IBD, so the 2018 signal holds at scale. Cook (2009) once said only mild GI issues like constipation rise in autism; Maunoo’s 2018 data move the needle to full-blown IBD, updating the story. Bottema-Beutel et al. (2023) add a twist: gut pain and internalizing symptoms fuel each other. So the bowel disease flagged in 2018 can loop back and worsen anxiety or self-injury you see in session.
Why it matters
If a learner suddenly hits more SIB, loses sleep, or avoids food, think below the belt. Ask parents about bloody stool, weight loss, or long bathroom trips. A quick GI referral can cut pain and may even drop problem behavior without extra ABA hours.
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02At a glance
03Original abstract
Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn's disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD.
Journal of autism and developmental disorders, 2018 · doi:10.1007/s10803-017-3409-5