Autism & Developmental

Association of Autism Spectrum Disorders and Inflammatory Bowel Disease.

Lee et al. (2018) · Journal of autism and developmental disorders 2018
★ The Verdict

Autism and inflammatory bowel disease travel together—track bowel health to protect learning gains.

✓ Read this if BCBAs serving school-age or adolescent clients with autism who show sudden behavior spikes.
✗ Skip if Clinicians already partnered with pediatric GI teams doing routine IBD screening.

01Research in Context

01

What this study did

Lee et al. (2018) looked at medical records of kids with autism and matched peers. They checked how many in each group had Crohn’s disease or ulcerative colitis. The design was a simple case-control review pulled from large health databases.

02

What they found

Kids with autism were more likely to meet full criteria for both Crohn’s and colitis. The link stayed strong after basic matching for age and sex. In plain words, IBD is not rare in autism; it shows up more than clinicians expect.

03

How this fits with other research

Kaiser et al. (2022) pooled over 11 million kids and found the same bump in IBD, so the 2018 signal holds at scale. Cook (2009) once said only mild GI issues like constipation rise in autism; Maunoo’s 2018 data move the needle to full-blown IBD, updating the story. Bottema-Beutel et al. (2023) add a twist: gut pain and internalizing symptoms fuel each other. So the bowel disease flagged in 2018 can loop back and worsen anxiety or self-injury you see in session.

04

Why it matters

If a learner suddenly hits more SIB, loses sleep, or avoids food, think below the belt. Ask parents about bloody stool, weight loss, or long bathroom trips. A quick GI referral can cut pain and may even drop problem behavior without extra ABA hours.

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→ Action — try this Monday

Add one bowel question to your caregiver check-in: any diarrhea, blood, or belly pain this week?

02At a glance

Intervention
not applicable
Design
other
Population
autism spectrum disorder
Finding
positive

03Original abstract

Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn's disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD.

Journal of autism and developmental disorders, 2018 · doi:10.1007/s10803-017-3409-5