Psychological correlates of handedness and corpus callosum asymmetry in autism: the left hemisphere dysfunction theory revisited.
Right-brain dominance helps some skills and hurts others in autism, so left-brain-only theories are outdated.
01Research in Context
What this study did
Matson et al. (2013) looked at handedness and brain shape in teens with autism. They used MRI to measure the corpus callosum, the bridge between the two sides of the brain.
They asked: does being more right-side dominant link to worse or better skills in autism? They scored symptom severity and IQ to find out.
What they found
Rightward brain bias helped thinking in some callosum areas but hurt in others. There was no clear link between hand use and autism traits.
The results were mixed, so the old idea that the left side is simply broken in autism is too simple.
How this fits with other research
Richmond (1983) first said autistic kids show left-side weakness on neuropsych tests. L et al. add brain pictures and handedness, showing the story is patchy, not one-sided.
Jouravlev et al. (2020) found less left-side language action in autistic adults. That seems to clash with L et al., but Olessia used speech tasks while L et al. looked at structure and hand skill. Different tools, different answers.
Ghaziuddin et al. (1996) saw hand choice was less steady in autistic children. L et al. echo this by finding no group hand difference, backing the idea that hand use alone does not flag autism.
Why it matters
Stop blaming every autism challenge on left-brain failure. Right-side areas can help or hurt depending on the task. When you test a client, pick tools that tap both sides and watch mixed profiles, not just one weak hemisphere.
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02At a glance
03Original abstract
Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization.
Journal of autism and developmental disorders, 2013 · doi:10.1016/0006-8993(91)91284-8