Assessment & Research

Perinatal Factors in Newborn Are Insidious Risk Factors for Childhood Autism Spectrum Disorders: A Population-based Study.

Lee et al. (2022) · Journal of autism and developmental disorders 2022
★ The Verdict

Four common newborn problems, especially slow growth and head-shape anomalies, sharply raise later autism odds.

✓ Read this if BCBAs who screen toddlers or write intake reports in clinics, hospitals, or early-intervention centers.
✗ Skip if Practitioners who only serve adults with autism and never see birth records.

01Research in Context

01

What this study did

A Taiwan team tracked every child born in one year. They later checked who got an autism diagnosis.

They looked at four newborn problems: jaundice, low blood sugar, slow growth in the womb, and unusual face or head shape.

The study used health records, so families did not need to fill out forms.

02

What they found

All four problems raised the odds of later autism. Slow growth and head-shape issues carried the biggest jump.

The group was large, so the link looks real for Taiwan babies.

03

How this fits with other research

Robinson et al. (2011) pooled 13 studies and saw the same jaundice signal. The Taiwan data fit right inside that older meta-analysis.

Mamidala et al. (2013) in India also found jaundice and birth stress linked to autism. Two continents, same story.

Chien et al. (2019) went one step further. They showed that kids with autism plus these birth issues had worse stereotypy and social scores. Risk factor papers now connect to day-to-day symptom strength.

04

Why it matters

When you review a child’s history, note jaundice, low sugar, slow growth, or craniofacial differences. Flag these kids for extra developmental checks. Early watch means earlier teaching and better outcomes.

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Add a quick checkbox for jaundice, hypoglycemia, IUGR, and craniofacial anomalies to your intake form.

02At a glance

Intervention
not applicable
Design
quasi experimental
Sample size
62051
Population
autism spectrum disorder
Finding
positive

03Original abstract

We analyzed claims data from the Taiwan National Health Insurance database, which contains data of 23.5 million Taiwan residents. We included children born after January 1, 2000 who had received a diagnosis of autism spectrum disorders (ASD). Patients who were not diagnosed with ASD were included in the control group. The ASD prevalence was 517 in 62,051 (0.83%) children. Neonatal jaundice, hypoglycemia, intrauterine growth retardation (IUGR), and craniofacial anomalies (CFA) differed significantly between the ASD and control groups. After logistic regressive analysis, the adjusted odds ratios of IUGR, CFA, neonatal hypoglycemia, and neonatal jaundice were 8.58, 7.37, 3.83, and 1.32, respectively. Those insidiously perinatal risk factors, namely CFA, IUGR, neonatal hypoglycemia, and neonatal jaundice, could increase the risk of ASD.

Journal of autism and developmental disorders, 2022 · doi:10.1542/peds.2016-1813