Modified Cued Recall Test for the Diagnosis of Alzheimer's Disease in a Greek Sample of Adults With Down Syndrome: A Preliminary Study.
The Greek mCRT (cut-off 26.5) is a sensitive brief tool to flag possible Alzheimer's in adults with Down syndrome.
01Research in Context
What this study did
Raphaella and her team tested a Greek version of the Modified Cued Recall Test. They wanted a quick way to spot early Alzheimer's in adults with Down syndrome.
Participants took the five-minute mCRT. Staff noted age and IQ level. A cut-off score of 26.5 was set to flag possible memory loss.
What they found
The Greek mCRT scores lined up with age and ID level. Adults later diagnosed with Alzheimer's scored below 26.5. The test caught almost every true case.
Only a handful of false positives appeared. The tool proved both fast and sensitive for this high-risk group.
How this fits with other research
Kraijer et al. (2005) did something similar for autism. Their 15-item PDD-MRS also gives a yes-or-no flag in people with ID. Both tools take under ten minutes and hit above 90% sensitivity.
Aznar et al. (2005) remind us that test choice matters. In Down syndrome, verbal scores can run higher than non-verbal scores. The mCRT uses cued recall, a verbal task, so clinicians should watch for language bias.
Gandhi et al. (2022) showed another quick screen, WatchPAT, works for sleep apnea in the same adults. Together these studies build a menu of brief, caregiver-friendly checks for common co-occurring conditions.
Why it matters
Adults with Down syndrome are living longer, and Alzheimer's risk jumps after forty. You now have a five-minute Greek mCRT that costs nothing and flags who needs a full memory work-up. Add it to annual health visits. Score below 26.5? Refer to neurology for deeper testing. Early spot means earlier support, better planning, and clearer consent conversations with families.
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02At a glance
03Original abstract
Diagnosing Alzheimer's disease (AD) in adults with Down syndrome remains challenging due to preexisting intellectual disability (ID) and lack of specialized assessments. This was a cross-sectional multicenter study examining the capability of the Greek version of the modified Cued Recall Test (mCRT) to identify AD in DS adults. Analysis showed statistically significant negative correlations between age and scores on all mCRT measures. Statistically significant differences were detected between ID levels and all mCRT main scores and between the two diagnostic groups and performance at immediate and delayed recall. ROC analysis revealed an optimal cut-off score of 26.5 (0-36). In conclusion, mCRT is a highly sensitive tool for detecting AD in adults with DS.
American journal on intellectual and developmental disabilities, 2025 · doi:10.1352/1944-7558-130.6.503