Assessment & Research

Modified Cued Recall Test for the Diagnosis of Alzheimer's Disease in a Greek Sample of Adults With Down Syndrome: A Preliminary Study.

Paradisi et al. (2025) · American journal on intellectual and developmental disabilities 2025
★ The Verdict

The Greek mCRT (cut-off 26.5) is a sensitive brief tool to flag possible Alzheimer's in adults with Down syndrome.

✓ Read this if BCBAs doing annual assessments or caregiver training with Greek-speaking adults with Down syndrome.
✗ Skip if Practitioners serving only non-Greek speakers or clients under 25.

01Research in Context

01

What this study did

Raphaella and her team tested a Greek version of the Modified Cued Recall Test. They wanted a quick way to spot early Alzheimer's in adults with Down syndrome.

Participants took the five-minute mCRT. Staff noted age and IQ level. A cut-off score of 26.5 was set to flag possible memory loss.

02

What they found

The Greek mCRT scores lined up with age and ID level. Adults later diagnosed with Alzheimer's scored below 26.5. The test caught almost every true case.

Only a handful of false positives appeared. The tool proved both fast and sensitive for this high-risk group.

03

How this fits with other research

Kraijer et al. (2005) did something similar for autism. Their 15-item PDD-MRS also gives a yes-or-no flag in people with ID. Both tools take under ten minutes and hit above 90% sensitivity.

Aznar et al. (2005) remind us that test choice matters. In Down syndrome, verbal scores can run higher than non-verbal scores. The mCRT uses cued recall, a verbal task, so clinicians should watch for language bias.

Gandhi et al. (2022) showed another quick screen, WatchPAT, works for sleep apnea in the same adults. Together these studies build a menu of brief, caregiver-friendly checks for common co-occurring conditions.

04

Why it matters

Adults with Down syndrome are living longer, and Alzheimer's risk jumps after forty. You now have a five-minute Greek mCRT that costs nothing and flags who needs a full memory work-up. Add it to annual health visits. Score below 26.5? Refer to neurology for deeper testing. Early spot means earlier support, better planning, and clearer consent conversations with families.

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→ Action — try this Monday

Print the Greek mCRT sheet, set a timer for five minutes, and trial-run it with one adult client; note any words they miss and total the score.

02At a glance

Intervention
not applicable
Design
other
Population
down syndrome
Finding
positive

03Original abstract

Diagnosing Alzheimer's disease (AD) in adults with Down syndrome remains challenging due to preexisting intellectual disability (ID) and lack of specialized assessments. This was a cross-sectional multicenter study examining the capability of the Greek version of the modified Cued Recall Test (mCRT) to identify AD in DS adults. Analysis showed statistically significant negative correlations between age and scores on all mCRT measures. Statistically significant differences were detected between ID levels and all mCRT main scores and between the two diagnostic groups and performance at immediate and delayed recall. ROC analysis revealed an optimal cut-off score of 26.5 (0-36). In conclusion, mCRT is a highly sensitive tool for detecting AD in adults with DS.

American journal on intellectual and developmental disabilities, 2025 · doi:10.1352/1944-7558-130.6.503