Assessment & Research

Hemispheric asymmetries, fourth ventricular size, and cerebellar morphology in autism.

Rumsey et al. (1988) · Journal of autism and developmental disorders 1988
★ The Verdict

Old CT scans found no outer brain differences between autistic and non-autistic adults.

✓ Read this if BCBAs who field medical questions from parents or team members.
✗ Skip if Clinicians only interested in modern functional imaging.

01Research in Context

01

What this study did

Doctors took CT brain scans of adults with autism and adults without it.

They measured the size of the fourth ventricle and looked at the cerebellum.

They also checked if the left and right sides of the brain were different sizes.

02

What they found

The scans looked the same in both groups.

No extra large ventricles. No shrunken cerebellum. No lopsided hemispheres.

In short, the brains showed no outer signs of autism.

03

How this fits with other research

Bromley et al. (1998) later used better MRI machines and still found no size gap in the hippocampus.

Pilgrim et al. (2000) ran a simple eye-movement test and saw normal cerebellar reflexes in autistic kids.

Laidi et al. (2019) seems to clash: they found thinner cortex in one spot. The gap likely comes from newer MRI that can measure paper-thin layers, while 1988 CT only saw big shapes.

Worsham et al. (2015) went deeper, showing weaker talk between hemispheres with EEG. No shape problem, but a wiring problem.

04

Why it matters

This paper tells you not to expect clear brain shape clues on a basic scan. When families ask, "Will an MRI show autism?" you can say outer shape usually looks typical. Focus your energy on behavior and learning history, not hunting for a cerebellar smoking gun.

Free CEUs

Want CEUs on This Topic?

The ABA Clubhouse has 60+ free CEUs — live every Wednesday. Ethics, supervision & clinical topics.

Join Free →
→ Action — try this Monday

Explain to families that a "normal" brain scan is common in autism and doesn’t rule out the diagnosis.

02At a glance

Intervention
not applicable
Design
case control
Sample size
15
Population
autism spectrum disorder
Finding
null

03Original abstract

Hemispheric asymmetries, fourth ventricular size, and cerebellar morphology were examined in 15 healthy men, aged 18 to 39 years, with documented childhood diagnoses of infantile autism, and in 20 healthy age- and sex-matched controls using computerized transverse axial tomography (CT). Nine patients were of approximately average intelligence, 3 showed specific language impairments, and 3 were mentally retarded. No significant group differences were seen in the distributions of frontal or posterior asymmetries of width or petalia. No subject showed evidence of cerebellar atrophy or an enlarged fourth ventricle. These results fail to support a hypothesis of unusual hemispheric asymmetry or macroscopic abnormalities of the posterior fossa in autism.

Journal of autism and developmental disorders, 1988 · doi:10.1007/BF02211823