Habituation, Adaptation and Prediction Processes in Neurodevelopmental Disorders: A Comprehensive Review.
Slow habituation and weak neural adaptation are measurable, trans-diagnostic markers that help explain insistence on sameness in autism and related conditions.
01Research in Context
What this study did
Waldron et al. (2023) pulled together every paper they could find on habituation, adaptation, and prediction in autism, ADHD, and schizophrenia. They did not run new tests. They read, grouped, and mapped how well each diagnosis dampens down repeating sights, sounds, or touches.
The goal was to see if slow habituation and weak neural adaptation could explain why many clients insist on sameness and miss small changes.
What they found
Across dozens of studies, people with ASD, ADHD, or schizophrenia kept showing the same pattern: their brains stayed alert to stimuli that most minds already tagged as old news. The review links that sticky brain state to everyday rigidity and change-detection slips.
In plain words, the ‘same old’ never feels old, so the world always feels too loud, too bright, or too new.
How this fits with other research
Redquest et al. (2021) used skin sensors and brain scans to prove autistic listeners need longer to tune out repeating beeps. A et al. weave that finding into their bigger story.
Liu (2025) adds a twist: pre-attentive circuits work fine, but once attention is required, the change marker fades. The review folds that stage-by-stage picture into its habituation map.
van Laarhoven et al. (2019) show the self-talk loop is also broken; autistic clients do not dampen sounds they make themselves. A et al. slot that motor-auditory gap under the same prediction-error umbrella.
Why it matters
You now have a concrete story to share with parents and teachers: the child is not ‘choosing’ to over-react; the sensory brake pedal is late. Use that frame to justify slow, repeated exposure programs, warn against sudden schedule swaps, and select objective brain or skin measures to track progress instead of relying only on caregiver reports.
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02At a glance
03Original abstract
Habituation, the simplest form of learning preserved across species and evolution, is characterized by a response decrease as a stimulus is repeated. This adaptive function has been shown to be altered in some psychiatric and neurodevelopmental disorders such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD) or schizophrenia. At the brain level, habituation is characterized by a decrease in neural activity as a stimulation is repeated, referred to as neural adaptation. This phenomenon influences the ability to make predictions and to detect change, two processes altered in some neurodevelopmental and psychiatric disorders. In this comprehensive review, the objectives are to characterize habituation, neural adaptation, and prediction throughout typical development and in neurodevelopmental disorders; and to evaluate their implication in symptomatology, specifically in sensitivity to change or need for sameness. A summary of the different approaches to investigate adaptation will be proposed, in which we report the contribution of animal studies as well as electrophysiological studies in humans to understanding of underlying neuronal mechanisms.
, 2023 · doi:10.3390/brainsci13071110