Assessment & Research

Eye-Tracking in Infants and Young Children at Risk for Autism Spectrum Disorder: A Systematic Review of Visual Stimuli in Experimental Paradigms.

Mastergeorge et al. (2021) · Journal of autism and developmental disorders 2021
★ The Verdict

Eye-tracking can flag autism risk, but only if labs stop swapping pictures and agree on one standard set.

✓ Read this if BCBAs who screen toddlers for ASD or collect eye-tracking data.
✗ Skip if Clinicians only doing adult or verbal assessments.

01Research in Context

01

What this study did

Higgins et al. (2021) looked at every eye-tracking paper that tried to spot autism in babies and toddlers. They wanted to see what pictures, videos, or objects each lab used.

The team found dozens of different setups. Some labs showed faces. Others showed toys or dots. No two used the same rules.

02

What they found

The review says the field is a mess. Stimuli, timing, and scoring change from lab to lab. Because of that, results rarely repeat.

Until labs agree on one standard kit, eye-tracking cannot be trusted as a screen for autism.

03

How this fits with other research

Ma et al. (2021) meta-analysis agrees that kids with autism look less at eyes. Their numbers show the signal is real, but small. M et al. explain why: every lab tweaks the task.

da Silva et al. (2025) moved the idea into the real world. They tracked toddlers in nursery rooms and still found a weak but usable effect. Their field data prove the signal survives even with the messy protocols M et al. warn about.

Vernetti et al. (2024) cut the task to 30 seconds of live play. Manual coding worked better than automatic tracking, echoing Falck-Ytter et al. (2015). Both studies back M et al.'s call for tighter, simpler methods.

04

Why it matters

You can keep using eye-tracking as a red-flag tool, but do not treat it like a blood test. Pick one short, face-based protocol and stick with it. Share your stimuli and code so the field can finally build the shared kit this review says we need.

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Use a 30-second face video with manual coding; post your protocol online for others to copy.

02At a glance

Intervention
not applicable
Design
systematic review
Population
autism spectrum disorder
Finding
not reported

03Original abstract

Eye-tracking represents a sensitive, direct measure of gaze allocation and goal-directed looking behaviors that correspond to visual information processing. Clear definitions and standardization of research protocols to document the utility and feasibility of these methods are warranted. This systematic review provides an account of stimuli dimensions and experimental paradigms used in eye-tracking research for young children at risk for ASD published from 2005 through 2019. This review identifies variability in eye-tracking protocols and heterogeneity of stimuli used for eye-tracking as factors that undermine the value of eye-tracking as an objective, reliable screening tool. We underscore the importance of sharing eye-tracking stimuli to enhance replicability of findings and more importantly the need to develop a bank of publicly available, validated stimuli.

Journal of autism and developmental disorders, 2021 · doi:10.1111/desc.12961