Assessment & Research

Current investigations in autism brain tissue research.

Pickett (2001) · Journal of autism and developmental disorders 2001
★ The Verdict

Brain donations drive the hunt for autism’s neural roots, and newer studies keep building on that early roadmap.

✓ Read this if BCBAs who field parent questions about how autism research works.
✗ Skip if Clinicians looking for quick behavior-change tactics.

01Research in Context

01

What this study did

Delprato (2001) wrote a story-style review. It lists every autism brain-tissue project running at the time.

The paper says families can donate brain tissue after death. Labs then pair the tissue with MRI and gene tests.

No new numbers are given. The goal is to map where autism starts in the brain.

02

What they found

The review found a small network of brain banks. Each bank needs more donors.

Teams were mixing old-school anatomy with new gene chips. No final answers yet.

03

How this fits with other research

Amiri et al. (2020) extends this work. They swapped the microscope for a birth-cohort file. Instead of dead tissue, they tracked 920 pre-birth events in living babies. Both papers still hunt autism causes, just at different life stages.

Griffith et al. (2012) stays in the same lane. Their review says one brain loop — cortical-basal ganglia — may feed both stereotypy and self-injury. Delprato (2001) shows where to cut the tissue; Griffith et al. (2012) tells you what circuit to look for.

van der Lubbe et al. (2025) move the lens upstairs. They measure hair cortisol in stressed parents and kids. Delprato (2001) digs into brain cells; van der Lubbe et al. (2025) show how chronic stress hormones travel through the whole family. Together they link brain structure to body chemistry.

04

Why it matters

You can’t order an brain biopsy for a client, but you can join the donor list as a family resource. Share the brain-bank hotline with grieving families who ask how to help science. One day their gift may give you a clear neural target for the behaviors you treat today.

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Print the Autism BrainNet flyer and add it to your parent resource rack.

02At a glance

Intervention
not applicable
Design
narrative review
Population
autism spectrum disorder
Finding
not reported

03Original abstract

Brain tissue research has developed into a high-tech, multifaceted approach to understanding neurological disorders. Directed toward autism spectrum disorders, this investigative approach combines with other disciplines, such as imaging and genetics, to help explain the range and intensity of behaviors that characterize these disorders. This report is intended as an update on current autism brain research efforts and has a dual purpose: first, to disseminate information to the scientific community in the hope of stimulating more thinking about autism research and future collaborations; and second, to let the autism community know what is happening with this precious resource that was donated in the hope of determining the cause of autism and finding effective treatments.

Journal of autism and developmental disorders, 2001 · doi:10.1023/a:1013282524687