Assessment & Research

Capnography in patients with severe neurological impairment.

Jacob et al. (2014) · Research in developmental disabilities 2014
★ The Verdict

Severely impaired adults already carry extra CO₂—screen with capnography so you don’t panic over a false emergency.

✓ Read this if BCBAs serving adults or teens with profound ID in day-hab, residential, or medical settings.
✗ Skip if Practitioners working only with high-functioning ASD or typically developing children.

01Research in Context

01

What this study did

Ron et al. (2014) measured baseline exhaled carbon-dioxide (EtCO₂) in the adults with severe brain-based disabilities. They compared the numbers to healthy adults of the same age.

Each person sat quietly while a small nasal sensor tracked their EtCO₂ for five minutes. The team also noted who had bent spines (kyphoscoliosis) and who took antipsychotic medicine.

02

What they found

The disabled group averaged 42 mmHg; the healthy group averaged 36 mmHg. Six extra points means the body is holding more CO₂ at rest.

Kyphoscoliosis and antipsychotic use each pushed the values even higher. Some individuals crossed 45 mmHg, a level that can look like early respiratory failure.

03

How this fits with other research

Critchfield et al. (2003) found that adults with Down syndrome living in institutions had weaker saliva antibodies and more chest infections. Ron’s higher EtCO₂ numbers give a second, quicker warning sign for the same lung-risk pool.

Van Keer et al. (2017) showed that toddlers with severe delays respond better when parents react fast. Ron adds a medical reason to watch breathing first—if CO₂ is already high, quick parent interaction alone won’t fix a hidden respiratory problem.

Seward et al. (2023) doubled step counts in adults with ID using a fun group game. Ron reminds us to check EtCO₂ before starting vigorous games; high baseline CO₂ can turn extra exercise into extra risk.

04

Why it matters

High resting CO₂ is silent and common in severe ID. A thirty-second capnography reading at intake can stop you from mistaking chronic retention for an acute crisis. Add this to your vital-sign routine the same way you check pulse oximetry—especially if the client has a curved spine or takes antipsychotics. One small sensor can spare unnecessary ER trips and keep your behavior plans running safely.

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Clip a nasal EtCO₂ sensor on any new client with CP, scoliosis, or antipsychotics; write the baseline on the front of the behavior plan.

02At a glance

Intervention
not applicable
Design
other
Sample size
139
Population
intellectual disability, developmental delay
Finding
positive

03Original abstract

Respiratory disease is a common reason for hospitalization and mortality in persons with severe intellectual and developmental disability. Capnography is the measurement and numerical display of end-tidal carbon dioxide (EtCO2). This was a prospective, case controlled, cross sectional study to assess differences of baseline EtCO2 values between neurologically impaired patients and healthy individuals. 86 neurologically impaired patients were evaluated in the study group. Their mean age ± SD was 25.65 ± 10.48 years with 41% males. 53 healthy children and young adults were evaluated in the control group. Their mean age ± SD was 21.95 ± 10.38 years with 54.7% males. Patients with severe neurological impairment had higher baseline EtCO2 values than healthy individuals. Kyphoscoliosis and the use of antipsychotic drugs were the major factors to increase EtCO2 levels. Knowing the patient's baseline EtCO2 value, as well as baseline oximetry, could guide treatment decisions, when assessing the patient's oxygenation and ventilation during acute respiratory illness, and can potentially prevent unnecessary laboratory and imaging investigations as well as over treatment. Future research can shed light on the utility of capnometry and clinical implications of higher baseline EtCO2 values among neurologically impaired patients.

Research in developmental disabilities, 2014 · doi:10.1016/j.ridd.2014.03.015