Assessment & Research

Brief report: comparability of DSM-IV and DSM-5 ASD research samples.

Mazefsky et al. (2013) · Journal of autism and developmental disorders 2013
★ The Verdict

Using ADOS and ADI-R together keeps 93% of high-functioning kids in the DSM-5 autism category.

✓ Read this if BCBAs who run intake evaluations or rely on published research samples.
✗ Skip if Clinicians who only use parent questionnaires and never touch ADOS/ADI-R.

01Research in Context

01

What this study did

The team asked a simple question. Will our research kids still have autism under the new DSM-5 rules?

They looked at high-functioning children who already had DSM-IV autism. Each child took two gold-standard tests: the ADOS and the ADI-R. Then they checked who still met DSM-5 criteria.

02

What they found

When both tests were used together, 93% of the children kept the diagnosis. The sample stayed almost the same.

That means old DSM-IV research groups remain valid for future DSM-5 studies.

03

How this fits with other research

Che Daud et al. (2026) back this up in a giant review. They show that ADOS plus ADI-R is still the world’s main diagnostic pair. Their map of 10 years of data includes the 93% figure you just read.

Cholemkery et al. (2016) dig deeper into the same ADI-R numbers. They found three severity clusters, not separate sub-types. Their gradient view supports keeping the whole group together, exactly what Fahmie et al. (2013) proved possible.

Beggiato et al. (2017) sound a warning. They found ADI-R items can under-score girls. So the 93% continuity is true overall, but clinicians should watch for gender bias and add extra tools when needed.

04

Why it matters

You can trust past high-functioning autism studies that used both ADOS and ADI-R. Keep using the pair for intake assessments to stay aligned with DSM-5. If you evaluate girls, add a gender-sensitive lens or second tool so no one slips through the cracks.

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→ Action — try this Monday

Pull last month’s intake files and note which ones had both ADOS and ADI-R; flag any girl who barely met criteria for a second look.

02At a glance

Intervention
not applicable
Design
other
Sample size
498
Population
autism spectrum disorder
Finding
positive
Magnitude
large

03Original abstract

Diagnostic and Statistical Manual (DSM-5) criteria for ASD have been criticized for being too restrictive, especially for more cognitively-able individuals. It is unclear, however, if high-functioning individuals deemed eligible for research via standardized diagnostic assessments would meet DSM-5 criteria. This study investigated the impact of DSM-5 on the diagnostic status of 498 high-functioning participants with ASD research diagnoses. The percent of participants satisfying all DSM-5-requirements varied significantly with reliance on data from the Autism Diagnostic Observation Schedule (ADOS; 33 %) versus Autism Diagnostic Interview-Revised (ADI-R; 83 %), highlighting the impact of diagnostic methodology on ability to document DSM-5 symptoms. Utilizing combined ADOS/ADI-R data, 93 % of participants met DSM-5 criteria, which suggests likely continuity between DSM-IV and DSM-5 research samples characterized with these instruments in combination.

Journal of autism and developmental disorders, 2013 · doi:10.1007/s10803-012-1560-6