Assessment & Research

Antenatal ultrasound and risk of autism spectrum disorders.

Grether et al. (2010) · Journal of autism and developmental disorders 2010
★ The Verdict

Routine prenatal ultrasounds do not increase autism risk, so BCBAs can ease parent guilt around standard imaging.

✓ Read this if BCBAs who field parent questions about what caused a child’s autism.
✗ Skip if Clinicians only focused on post-diagnosis skill building.

01Research in Context

01

What this study did

Researchers compared ultrasound records for kids later diagnosed with autism and kids without autism.

They counted every scan across all three trimesters.

The groups were matched so other birth factors would not cloud the picture.

02

What they found

Kids with autism had the same number of pre-birth scans as kids without autism.

No trimester showed a bump or drop in scan counts.

The result was flat: ultrasound exposure did not raise autism odds.

03

How this fits with other research

Chien et al. (2015) saw a small jump in autism risk when moms had general anesthesia for C-section.

That sounds opposite, but the exposures differ: routine imaging versus major surgery drugs.

Nicholson et al. (2017) also found nothing when they checked newborn thyroid blood spots, another null that keeps ultrasound company.

He et al. (2024) pooled many studies and agreed: labor and childhood anesthesia look safe, backing the larger pattern that common prenatal events rarely cause autism.

04

Why it matters

You can tell worried parents that normal pregnancy ultrasounds have no proven link to autism.

Save your clinical energy for factors with solid evidence, like maternal diabetes or PCOS flagged by Bravo-Muñoz et al. (2025).

Keep watching for new data, but for now ultrasound fears can go on the shelf.

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If a parent mentions ultrasound worry, share that large comparisons show no extra scans in kids with autism.

02At a glance

Intervention
not applicable
Design
quasi experimental
Sample size
755
Population
autism spectrum disorder
Finding
null
Magnitude
negligible

03Original abstract

We evaluated antenatal ultrasound (U/S) exposure as a risk factor for autism spectrum disorders (ASD), comparing affected singleton children and control children born 1995-1999 and enrolled in the Kaiser Permanente health care system. Among children with ASD (n = 362) and controls (n = 393), 13% had no antenatal exposure to U/S examinations; case-control differences in number of exposures during the entire gestation or by trimester were small and not statistically significant. In analyses adjusted for covariates, cases were generally similar to controls with regard to the number of U/S scans throughout gestation and during each trimester. This study indicates that antenatal U/S is unlikely to increase the risk of ASD, although studies examining ASD subgroups remain to be conducted.

Journal of autism and developmental disorders, 2010 · doi:10.1007/s10803-009-0859-4