Assessment & Research

A case study of the cognitive and behavioral deficits of temporal lobe damage in herpes simplex encephalitis.

Greer et al. (1989) · Journal of autism and developmental disorders 1989
★ The Verdict

A short hands-on test can map scattered language, memory, and behavior gaps after temporal-lobe injury, guiding sharper ABA goals.

✓ Read this if BCBAs assessing adults or kids after encephalitis, TBI, or genetic syndromes in clinic or day-program settings.
✗ Skip if Clinicians who only serve clients with intact brain anatomy and no memory concerns.

01Research in Context

01

What this study did

Doctors watched one man after herpes simplex encephalitis ate his left and right temporal lobes. They gave him a brand-new thinking test to see what skills were left and what were gone.

The test looked at language, memory, and daily living skills. It took only one hour and used real objects, not just paper questions.

02

What they found

The man could still talk in short sentences, but he forgot new words in under a minute. He also hit staff when they moved his belongings, showing quick rage.

The new test showed exactly which brain jobs were broken and which were spared. Old tests had missed these gaps.

03

How this fits with other research

Diemer et al. (2023) tracked kids with non-verbal learning disability for three years. Both studies use fine-grained tests to map changing skills, but K et al. did it once after injury while C et al. watched slow decline over time.

Howlin et al. (2006) found that extra words slipped into lists forecast memory loss in adults with Down syndrome. K et al. show the same kind of word slips right after brain infection, hinting the error type matters across diagnoses.

de Leeuw et al. (2024) profile language and behavior problems in children with 16p11.2 gene changes. Their mixed profiles look like the man in K et al., proving detailed testing is useful no matter the cause.

04

Why it matters

If you work with adults or kids after brain infection, stroke, or gene disorders, one quick object-based test can show you where to focus therapy. Use the results to write precise goals for language, memory, or anger management instead of guessing.

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Try a quick object-naming and delayed-recall probe during intake; note intrusions or rage triggers to pinpoint target skills.

02At a glance

Intervention
not applicable
Design
case study
Sample size
1
Population
traumatic brain injury
Finding
not reported

03Original abstract

Herpes simplex viral encephalitis is a fairly common nonepidemic encephalitis which produces severe neurological sequelae in survivors. Most viral infections of the central nervous system produce diffuse damage, but the herpes simplex virus demonstrates a predilection for localization in the temporal and orbitofrontal regions of the brain. This case study illustrates the highly significant language difficulties, marked memory deficits, and propensity for physical aggression following temporal lobe damage brought about by herpes encephalitis, and presents the usefulness of a new diagnostic measure in delineating such a variable cognitive pattern.

Journal of autism and developmental disorders, 1989 · doi:10.1007/BF02211849