Prader-Willi syndrome and psychotic symptoms: 1. Case descriptions and genetic studies.

Doctors wrote up six patients with Prader-Willi syndrome who later showed psychotic symptoms.

They checked each person’s chromosome 15 deletion or maternal-disomy status to see if genes predicted the mental-health outcome.

Psychosis appeared in both genetic forms—deletion and maternal uniparental disomy.

No single gene pattern shielded anyone from psychiatric risk.

Sinnema et al. (2011) later counted 119 adults and sharpened the picture: 64 % of the maternal-disomy group had psychiatric illness versus 17 % of the deletion group.

That looks like a clash, but it isn’t. D et al. simply showed psychosis can happen in either subtype; Margje et al. showed how often.

Mansell et al. (2002) added a roadmap: toddlers who are hyper and show autistic traits are the ones most likely to develop later psychosis, giving you an early warning sign.

You can’t relax mental-health monitoring just because a genetic report says “deletion.” Watch for mood swings, hallucinations, or rigid food thoughts in every client with PWS, and refer early to psychiatry. Track toddler temperament for the hyper-alert profile and flag those cases for closer follow-up.